老年人不明病因的慢性湿疹性皮炎停药试验的频率和效用:一项回顾性队列研究。

IF 4 3区 医学 Q1 DERMATOLOGY
Dermatitis Pub Date : 2023-09-01 Epub Date: 2023-05-12 DOI:10.1089/derm.2022.0104
Amy M Hopkins, Kimberly Lerner, Erin Grinich, Jiyoung Ahn, Yusung Choi, Jon Hanifin, Eric Simpson
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引用次数: 0

摘要

背景:湿疹性皮炎是老年人顽固性瘙痒症发作的主要原因。尽管有一些药物受到影响,但证明药物变化效用的数据有限。目的:探讨停药试验(DCTs)在老年人慢性湿疹样皮疹(CEEA)中的作用和可能的危害。方法:这是一项回顾性队列研究,利用DCTs的电子健康记录对65岁以上患有CEEA的成年人进行研究。结果:我们发现646名年龄在65岁以上的新发湿疹样皮疹患者,其中89人(14%)没有明确的病因。在该队列中,35名患者共接受了40次DCT。尽管有17.5%(7/40)的患者提到病情有所改善,但所有患者都因其持续性皮疹寻求三级护理。45%(18/40)的患者出现了阴性结果,所有这些结果都是由于药物治疗的合并症恶化所致。结论:我们的经验表明,CEEA患者接受的DCT并不能改善他们的皮炎,并可能导致潜在疾病的危险恶化。需要进一步研究CEEA的病因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Frequency and Utility of Drug Cessation Trials in Older Adults With Chronic Eczematous Dermatitis of Unknown Etiology: A Retrospective Cohort Study.

Background: Eczematous dermatitis is a major cause of recalcitrant pruritic eruptions in older adults. Although some medications have been implicated, there are limited data demonstrating the utility of medication changes. Objective: To investigate the utility and possible harms of drug cessation trials (DCTs) in chronic eczematous eruptions in the aging (CEEA). Methods: This is a retrospective cohort study utilizing electronic health records of DCTs in adults older than 65 years with CEEA. Results: We identified 646 patients >65 years with new onset eczematous eruptions, 89 (14%) of whom had no identifiable etiology. In this cohort, 35 patients underwent a total of 40 DCTs. Although there was mention of improvement in 17.5% (7/40), all patients sought tertiary care for their persistent rash. Negative outcomes occurred in 45% (18/40), all of which were due to exacerbation of a comorbidity that the medication was prescribed to treat. Conclusion: Our experience suggests that patients with CEEA undergo DCTs that do not improve their dermatitis and can lead to dangerous worsening of underlying conditions. Further study of the etiology of CEEA is needed.

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来源期刊
Dermatitis
Dermatitis 医学-皮肤病学
CiteScore
5.30
自引率
11.50%
发文量
251
审稿时长
>12 weeks
期刊介绍: Dermatitis is owned by the American Contact Dermatitis Society and is the home journal of 4 other organizations, namely Societa Italiana di Dermatologica Allergologica Professionale e Ambientale, Experimental Contact Dermatitis Research Group, International Contact Dermatitis Research Group, and North American Contact Dermatitis Group. Dermatitis focuses on contact, atopic, occupational, and drug dermatitis, and welcomes manuscript submissions in these fields, with emphasis on reviews, studies, reports, and letters. Annual sections include Contact Allergen of the Year and Contact Allergen Alternatives, for which papers are chosen or invited by the respective section editor. Other sections unique to the journal are Pearls & Zebras, Product Allergen Watch, and news, features, or meeting abstracts from participating organizations.
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