哈萨克人血脂参数与胰岛素抵抗的关系

IF 1.5 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Aizhan Shakhanova, Nurlan Aukenov, Alma Nurtazina, Alida Kasskabayeva, Meruyert Massabayeva, Dana Kenzhebayeva
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引用次数: 0

摘要

背景:胰岛素抵抗(IR)是慢性脂肪组织炎症的结果,是2型糖尿病、心血管疾病和代谢综合征等多种疾病的发病机制的基础。在这项研究中,我们研究了血脂异常与IR之间的关系;直接比较传统脂质比率和载脂蛋白/apoA1比率的强度和独立性作为哈萨克人群IR的危险因素。方法:本研究设计为病例对照研究。这项研究共有507名参与者。我们检查了每个参与者的血浆总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、载脂蛋白B和载脂蛋白A1。IR采用IR稳态模型评估(HOMA-IR)测定。为了评估致动脉粥样硬化血脂的风险,计算了致动脉粥样硬化系数:坏胆固醇与好胆固醇之比((TC-HDL)/HDL);TG /HDL比值(TRG/HDL);apoB/apoA1比值(apoB/apoA1)。结果:在本研究中,高腰围和BMI在男性中更为常见。有IR组的腰围(cm) (p = 0.0001)和BMI (kg/m2) (p = 0.04)明显高于无IR组。IR风险与apoB/apoA1比值显著相关(p = 0.03)。分析HOMA-IR与apoB/apoA1比值之间的关联,apoB/apoA1比值在0.71 - 0.85之间和0.86以上时,IR风险分别增加1.93和1.84倍。HOMA-IR水平与TG水平呈弱显著相关(rS = 0.3;p = 0.0001),与载脂蛋白ob水平呈极弱正相关(rS = 0.1;p = 0.002)和apoB/apoA1 (rS = 0.1;p = 0.001),与apoA1水平呈弱负相关(rS = -0.1;P = 0.02)。Logistic回归分析显示,男性发生IR的风险明显低于女性,校正OR (95% CI) = 0.75 (0.49-1.0) p = 0.02。结论:在我们的研究中,IR在哈萨克族女性中比在哈萨克族男性中更常见。IR也与载脂蛋白b和TG水平相关。因此,我们建议分析TG、apoB和apoB/apoA1比值可以作为哈萨克人群IR风险的早期预测指标(表3,参考文献22)。关键词:胰岛素抵抗,血脂异常,载脂蛋白,甘油三酯,脂质。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of lipid parameters with insulin resistance in the Kazakh population.

Background: Insulin resistance (IR) is a consequence of chronic adipose tissue inflammation and underlies the pathogenesis of several diseases, such as type 2 diabetes mellitus, cardiovascular diseases and metabolic syndrome. In this study, we examined the association between dyslipidaemia and IR; directly comparing conventional lipid ratios and apoB/apoA1 ratios for strength and independence as risk factors for IR in a Kazakh population.

Methods: The design of this study was a case-control study. There were 507 participants in the study. We examined each participant's plasma total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, apolipoprotein B, and apolipoprotein A1. IR was determined using an IR homeostasis model assessment (HOMA-IR). To assess the risk of an atherogenic blood lipid profile, atherogenicity coefficients were calculated: Bad cholesterol to good cholesterol ratio ((TC-HDL)/HDL); TG to HDL ratio (TRG/HDL); apoB to apoA1 ratio (apoB/apoA1).

Results: In this study, high waist circumference and BMI were more common in men. The group with IR had significantly higher waist circumference (cm) (p = 0.0001) and BMI (kg/m2) (p = 0.04) than the group without IR. The risk of IR was significantly associated with the apoB/apoA1 ratio (p = 0.03). Analysis of the association between HOMA-IR and apoB/apoA1 ratio increased the risk of IR at apoB/apoA1 ratios of 0.71 to 0.85 and above 0.86 by a factor of 1.93 and 1.84, respectively. HOMA-IR levels were weakly significantly correlated with TG levels (rS = 0.3; p = 0.0001) and very weakly positively correlated with apoB levels (rS = 0.1; p = 0.002) and apoB/apoA1 (rS = 0.1; p = 0.001), there was a weak negative correlation with apoA1 levels (rS = -0.1; p = 0.02). Logistic regression analysis showed that the risk of developing IR was significantly lower in men than in women, adjusted OR (95% CI) = 0.75 (0.49-1.0) p = 0.02.

Conclusion: In our study, IR was more common in Kazakh women than in Kazakh men. IR was also associated with apoB and TG levels. Thus, we suggest that analysis of TG, apoB and apoB/apoA1 ratio may be recommended as early predictors of IR risk in the Kazakh population (Tab. 3, Ref. 22). Text in PDF www.elis.sk Keywords: insulin resistance, dyslipidaemia, apolipoproteins, triglycerides, lipids.

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来源期刊
CiteScore
2.60
自引率
0.00%
发文量
185
审稿时长
3-8 weeks
期刊介绍: The international biomedical journal - Bratislava Medical Journal – Bratislavske lekarske listy (Bratisl Lek Listy/Bratisl Med J) publishes peer-reviewed articles on all aspects of biomedical sciences, including experimental investigations with clear clinical relevance, original clinical studies and review articles.
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