IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL
Christoph Sucker, Christof Geisen, Jens Litmathe, Ursula Schmitt
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引用次数: 0

摘要

诊断程序包括筛选分析,单凝血因子测定,遗传分析,也使用凝血酶生成测定(TGA)描述。此外,我们提出我们的考虑,关于发展充分预防出血与纤维蛋白原浓缩在这种情况下。本文简要讨论了有关这一问题的文献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Concomitant hypofibrinogenemia and factor XI deficiency as rare cause of bleeding during urgent dentistry: case report and short review of the literature.

Concomitant hypofibrinogenemia and factor XI deficiency as rare cause of bleeding during urgent dentistry: case report and short review of the literature.

Hypofibrinogenemia and Factor XI deficiency are rare defects of hemostasis, potentially leading to spontaneous bleeding manifestations and increased bleeding risk during surgery, dentistry, and interventions. Due to the different mode of inheritance, the concomitance of both defects is extremely rare and the clinical management of combined hypofibrinogenemia and factor XI deficiency is not standardized. Here, we report a rare case of concomitant genetically determined hypofibrinogenemia and factor XI deficiency as a cause of increased spontaneous bleeding and bleeding complications during dentistry. The diagnostic procedure including screening assays, single clotting factor determinations, genetic analyses, and also use of thrombin generation assays (TGA) are described. Also, we present our considerations regarding the development of an adequate prophylaxis of bleeding with fibrinogen concentrate in this case. The literature regarding the issue is briefly discussed.

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