新英格兰农村病例对照研究中的生活方式因素与帕金森病风险

IF 2.1 4区 医学 Q3 CLINICAL NEUROLOGY
Angeline S Andrew, Faith L Anderson, Stephen L Lee, Katharine M Von Herrmann, Matthew C Havrda
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引用次数: 1

摘要

帕金森病(PD)是一种与年龄相关的神经退行性疾病,可能是遗传和环境危险因素复杂相互作用的结果。暴露于杀虫剂、有毒金属、溶剂和创伤性脑损伤史被认为是帕金森病的环境危险因素,强调了在不同社区中识别与帕金森病相关的危险因素的重要性。方法:我们在新罕布什尔州/佛蒙特州边境的农村地区进行了一项基于问卷的病例对照研究,在2017年至2020年期间从普通人群中招募了PD患者和年龄和性别匹配的对照组。我们评估了频繁参与各种娱乐和职业活动的情况,并调查了潜在的化学接触。结果:诊断前患有“头部创伤或脑震荡”与PD风险增加四倍相关。头部创伤的调整否定了参加“剧烈运动活动”的任何风险。我们观察到与含铅活动相关的PD风险增加2.7倍(校正p=0.038)。结论:将这些因素与帕金森病风险联系起来,有利于减少暴露的公共卫生努力,同时也激发了未来的工作机制和干预机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lifestyle Factors and Parkinson's Disease Risk in a Rural New England Case-Control Study.

Introduction: Parkinson's disease (PD) is an age-related neurodegenerative disease likely caused by complex interactions between genetic and environmental risk factors. Exposure to pesticides, toxic metals, solvents, and history of traumatic brain injury have been implicated as environmental risk factors for PD, underscoring the importance of identifying risk factors associated with PD across different communities.

Methods: We conducted a questionnaire-based case-control study in a rural area on the New Hampshire/Vermont border, enrolling PD patients and age- and sex-matched controls from the general population between 2017 and 2020. We assessed frequent participation in a variety of recreational and occupational activities and surveyed potential chemical exposures.

Results: Suffering from "head trauma or a concussion" prior to diagnosis was associated with a fourfold increased risk of PD. Adjustment for head trauma negated any risk of participation in "strenuous athletic activities." We observed a 2.7-fold increased risk of PD associated with activities involving lead (adjusted p=0.038).

Conclusion: Implicating these factors in PD risk favors public health efforts in exposure mitigation while also motivating future work mechanisms and intervention opportunities.

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来源期刊
Parkinson's Disease
Parkinson's Disease CLINICAL NEUROLOGY-
CiteScore
5.80
自引率
3.10%
发文量
0
审稿时长
18 weeks
期刊介绍: Parkinson’s Disease is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the epidemiology, etiology, pathogenesis, genetics, cellular, molecular and neurophysiology, as well as the diagnosis and treatment of Parkinson’s disease.
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