Stephen M Siviy, Michelle A Martin, Celeste M Campbell
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As such, the F344 rat may be particularly useful for gaining insight into NE involvement in play.</p><p><strong>Objective: </strong>The objective of this study was to determine whether the F344 rat is differentially sensitive to compounds that affect NE functioning and that are known to affect play behavior.</p><p><strong>Methods: </strong>Using pouncing and pinning to quantify play, the effects of the NE reuptake inhibitor atomoxetine, the NE alpha-2 receptor agonist guanfacine, and the NE alpha-2 receptor antagonist RX821002 on play behavior were assessed in juvenile Sprague-Dawley (SD) and F344 rats.</p><p><strong>Results: </strong>Atomoxetine and guanfacine reduced play in both SD and F344 rats. RX821002 increased pinning to a comparable extent in both strains but F344 rats were more sensitive to the play-enhancing effects of RX821002 on pounces.</p><p><strong>Conclusions: </strong>Strain differences in NE alpha-2 receptor dynamics may contribute to the lower levels of play in F344 rats.</p>","PeriodicalId":20783,"journal":{"name":"Psychopharmacology","volume":" ","pages":"955-964"},"PeriodicalIF":3.5000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Noradrenergic modulation of play in Sprague-Dawley and F344 rats.\",\"authors\":\"Stephen M Siviy, Michelle A Martin, Celeste M Campbell\",\"doi\":\"10.1007/s00213-023-06419-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Rationale: </strong>For many mammals, engaging in social play behavior as a juvenile is important for cognitive, social, and emotional health as an adult. A playful phenotype reflects a dynamic interplay between genetic framework and experiences that operate on hard-wired brain systems so the relative lack of play in an otherwise playful species may be useful for identifying neural substrates that modulate play behavior. The inbred F344 rat has been identified as a strain that is consistently less playful than other strains commonly used in behavioral research. Norepinephrine (NE) acting on alpha-2 receptors has an inhibitory effect on play and F344 rats differ from a number of other strains in NE functioning. As such, the F344 rat may be particularly useful for gaining insight into NE involvement in play.</p><p><strong>Objective: </strong>The objective of this study was to determine whether the F344 rat is differentially sensitive to compounds that affect NE functioning and that are known to affect play behavior.</p><p><strong>Methods: </strong>Using pouncing and pinning to quantify play, the effects of the NE reuptake inhibitor atomoxetine, the NE alpha-2 receptor agonist guanfacine, and the NE alpha-2 receptor antagonist RX821002 on play behavior were assessed in juvenile Sprague-Dawley (SD) and F344 rats.</p><p><strong>Results: </strong>Atomoxetine and guanfacine reduced play in both SD and F344 rats. RX821002 increased pinning to a comparable extent in both strains but F344 rats were more sensitive to the play-enhancing effects of RX821002 on pounces.</p><p><strong>Conclusions: </strong>Strain differences in NE alpha-2 receptor dynamics may contribute to the lower levels of play in F344 rats.</p>\",\"PeriodicalId\":20783,\"journal\":{\"name\":\"Psychopharmacology\",\"volume\":\" \",\"pages\":\"955-964\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychopharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00213-023-06419-2\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/7/10 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychopharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00213-023-06419-2","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/7/10 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Noradrenergic modulation of play in Sprague-Dawley and F344 rats.
Rationale: For many mammals, engaging in social play behavior as a juvenile is important for cognitive, social, and emotional health as an adult. A playful phenotype reflects a dynamic interplay between genetic framework and experiences that operate on hard-wired brain systems so the relative lack of play in an otherwise playful species may be useful for identifying neural substrates that modulate play behavior. The inbred F344 rat has been identified as a strain that is consistently less playful than other strains commonly used in behavioral research. Norepinephrine (NE) acting on alpha-2 receptors has an inhibitory effect on play and F344 rats differ from a number of other strains in NE functioning. As such, the F344 rat may be particularly useful for gaining insight into NE involvement in play.
Objective: The objective of this study was to determine whether the F344 rat is differentially sensitive to compounds that affect NE functioning and that are known to affect play behavior.
Methods: Using pouncing and pinning to quantify play, the effects of the NE reuptake inhibitor atomoxetine, the NE alpha-2 receptor agonist guanfacine, and the NE alpha-2 receptor antagonist RX821002 on play behavior were assessed in juvenile Sprague-Dawley (SD) and F344 rats.
Results: Atomoxetine and guanfacine reduced play in both SD and F344 rats. RX821002 increased pinning to a comparable extent in both strains but F344 rats were more sensitive to the play-enhancing effects of RX821002 on pounces.
Conclusions: Strain differences in NE alpha-2 receptor dynamics may contribute to the lower levels of play in F344 rats.
期刊介绍：
Official Journal of the European Behavioural Pharmacology Society (EBPS)
Psychopharmacology is an international journal that covers the broad topic of elucidating mechanisms by which drugs affect behavior. The scope of the journal encompasses the following fields:
Human Psychopharmacology: Experimental
This section includes manuscripts describing the effects of drugs on mood, behavior, cognition and physiology in humans. The journal encourages submissions that involve brain imaging, genetics, neuroendocrinology, and developmental topics. Usually manuscripts in this section describe studies conducted under controlled conditions, but occasionally descriptive or observational studies are also considered.
Human Psychopharmacology: Clinical and Translational
This section comprises studies addressing the broad intersection of drugs and psychiatric illness. This includes not only clinical trials and studies of drug usage and metabolism, drug surveillance, and pharmacoepidemiology, but also work utilizing the entire range of clinically relevant methodologies, including neuroimaging, pharmacogenetics, cognitive science, biomarkers, and others. Work directed toward the translation of preclinical to clinical knowledge is especially encouraged. The key feature of submissions to this section is that they involve a focus on clinical aspects.
Preclinical psychopharmacology: Behavioral and Neural
This section considers reports on the effects of compounds with defined chemical structures on any aspect of behavior, in particular when correlated with neurochemical effects, in species other than humans. Manuscripts containing neuroscientific techniques in combination with behavior are welcome. We encourage reports of studies that provide insight into the mechanisms of drug action, at the behavioral and molecular levels.
Preclinical Psychopharmacology: Translational
This section considers manuscripts that enhance the confidence in a central mechanism that could be of therapeutic value for psychiatric or neurological patients, using disease-relevant preclinical models and tests, or that report on preclinical manipulations and challenges that have the potential to be translated to the clinic. Studies aiming at the refinement of preclinical models based upon clinical findings (back-translation) will also be considered. The journal particularly encourages submissions that integrate measures of target tissue exposure, activity on the molecular target and/or modulation of the targeted biochemical pathways.
Preclinical Psychopharmacology: Molecular, Genetic and Epigenetic
This section focuses on the molecular and cellular actions of neuropharmacological agents / drugs, and the identification / validation of drug targets affecting the CNS in health and disease. We particularly encourage studies that provide insight into the mechanisms of drug action at the molecular level. Manuscripts containing evidence for genetic or epigenetic effects on neurochemistry or behavior are welcome.
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