Yunxiu Zhang, Qingyan Jia, Jian Li, Jian Wang, Ke Liang, Xiaokuang Xue, Tiejin Chen, Lin Kong, Haohui Ren, Weimin Liu, Pengfei Wang, Jiechao Ge
{"title":"细菌氯化铜纳米片作为特异性Pyroposis诱导剂用于强大的肿瘤免疫治疗。","authors":"Yunxiu Zhang, Qingyan Jia, Jian Li, Jian Wang, Ke Liang, Xiaokuang Xue, Tiejin Chen, Lin Kong, Haohui Ren, Weimin Liu, Pengfei Wang, Jiechao Ge","doi":"10.1002/adma.202305073","DOIUrl":null,"url":null,"abstract":"<p>Pyroptosis is increasingly considered a new weathervane in cancer immune therapy. However, triggering specific pyroptotic tumor cell death while preserving normal cells still remains a major challenge. Herein, a brand-new pyroptosis inducer, copper-bacteriochlorin nanosheet (Cu-TBB), is designed. The synthesized Cu-TBB can be activated to an “on” state in the tumor microenvironment with glutathione (GSH) overexpression, leading to the release of Cu<sup>+</sup> and TBB, respectively. Intriguingly, the released Cu<sup>+</sup> can drive cascade reactions to produce O<sub>2</sub><sup>−•</sup> and highly toxic ·OH in cells. Additionally, the released TBB can also generate O<sub>2</sub><sup>−•</sup> and <sup>1</sup>O<sub>2</sub> upon 750 nm laser irradiation. Encouragingly, both Cu<sup>+</sup>-driven cascade reactions and photodynamic therapy pathways result in potent pyroptosis along with dendritic cell maturation and T cell priming, thus simultaneously eliminating the primary tumors and inhibiting the distant tumor growth and metastases. Conclusively, the well-designed Cu-TBB nanosheet is shown to trigger specific pyroptosis in vitro and in vivo, leading to enhanced tumor immunogenicity and antitumor efficacy while minimizing systemic side effects.</p>","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":null,"pages":null},"PeriodicalIF":27.4000,"publicationDate":"2023-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"Copper-Bacteriochlorin Nanosheet as a Specific Pyroptosis Inducer for Robust Tumor Immunotherapy\",\"authors\":\"Yunxiu Zhang, Qingyan Jia, Jian Li, Jian Wang, Ke Liang, Xiaokuang Xue, Tiejin Chen, Lin Kong, Haohui Ren, Weimin Liu, Pengfei Wang, Jiechao Ge\",\"doi\":\"10.1002/adma.202305073\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Pyroptosis is increasingly considered a new weathervane in cancer immune therapy. However, triggering specific pyroptotic tumor cell death while preserving normal cells still remains a major challenge. Herein, a brand-new pyroptosis inducer, copper-bacteriochlorin nanosheet (Cu-TBB), is designed. The synthesized Cu-TBB can be activated to an “on” state in the tumor microenvironment with glutathione (GSH) overexpression, leading to the release of Cu<sup>+</sup> and TBB, respectively. Intriguingly, the released Cu<sup>+</sup> can drive cascade reactions to produce O<sub>2</sub><sup>−•</sup> and highly toxic ·OH in cells. Additionally, the released TBB can also generate O<sub>2</sub><sup>−•</sup> and <sup>1</sup>O<sub>2</sub> upon 750 nm laser irradiation. Encouragingly, both Cu<sup>+</sup>-driven cascade reactions and photodynamic therapy pathways result in potent pyroptosis along with dendritic cell maturation and T cell priming, thus simultaneously eliminating the primary tumors and inhibiting the distant tumor growth and metastases. Conclusively, the well-designed Cu-TBB nanosheet is shown to trigger specific pyroptosis in vitro and in vivo, leading to enhanced tumor immunogenicity and antitumor efficacy while minimizing systemic side effects.</p>\",\"PeriodicalId\":114,\"journal\":{\"name\":\"Advanced Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":27.4000,\"publicationDate\":\"2023-07-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/adma.202305073\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Materials","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/adma.202305073","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Copper-Bacteriochlorin Nanosheet as a Specific Pyroptosis Inducer for Robust Tumor Immunotherapy
Pyroptosis is increasingly considered a new weathervane in cancer immune therapy. However, triggering specific pyroptotic tumor cell death while preserving normal cells still remains a major challenge. Herein, a brand-new pyroptosis inducer, copper-bacteriochlorin nanosheet (Cu-TBB), is designed. The synthesized Cu-TBB can be activated to an “on” state in the tumor microenvironment with glutathione (GSH) overexpression, leading to the release of Cu+ and TBB, respectively. Intriguingly, the released Cu+ can drive cascade reactions to produce O2−• and highly toxic ·OH in cells. Additionally, the released TBB can also generate O2−• and 1O2 upon 750 nm laser irradiation. Encouragingly, both Cu+-driven cascade reactions and photodynamic therapy pathways result in potent pyroptosis along with dendritic cell maturation and T cell priming, thus simultaneously eliminating the primary tumors and inhibiting the distant tumor growth and metastases. Conclusively, the well-designed Cu-TBB nanosheet is shown to trigger specific pyroptosis in vitro and in vivo, leading to enhanced tumor immunogenicity and antitumor efficacy while minimizing systemic side effects.
期刊介绍:
Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.