纳米尺度的核环境，精细尺度的三维基因组组织和转录调控

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current Opinion in Systems Biology Pub Date : 2022-09-01 DOI:10.1016/j.coisb.2022.100436

Jieru Li, Alexandros Pertsinidis

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引用次数: 1

摘要

几十年的体外生化重建、遗传学和结构生物学研究已经建立了染色质调控和转录的分子机制的庞大知识基础。剩下的挑战是了解这些复杂的生化系统如何在三维基因组组织的背景下以及在拥挤和分隔的核环境中运作。本文综述了基于高分辨率成像方法的这一领域的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nanoscale nuclear environments, fine-scale 3D genome organization and transcription regulation

Decades of in vitro biochemical reconstitution, genetics and structural biology studies have established a vast knowledge base on the molecular mechanisms of chromatin regulation and transcription. A remaining challenge is to understand how these intricate biochemical systems operate in the context of the 3D genome organization and in the crowded and compartmentalized nuclear milieu. Here we review recent progress in this area based on high-resolution imaging approaches.

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来源期刊

Current Opinion in Systems Biology Mathematics-Applied Mathematics

CiteScore

7.10

自引率

2.70%

发文量

期刊介绍： Current Opinion in Systems Biology is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of Systems Biology. It publishes polished, concise and timely systematic reviews and opinion articles. In addition to describing recent trends, the authors are encouraged to give their subjective opinion on the topics discussed. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following areas will be covered by Current Opinion in Systems Biology: -Genomics and Epigenomics -Gene Regulation -Metabolic Networks -Cancer and Systemic Diseases -Mathematical Modelling -Big Data Acquisition and Analysis -Systems Pharmacology and Physiology -Synthetic Biology -Stem Cells, Development, and Differentiation -Systems Biology of Mold Organisms -Systems Immunology and Host-Pathogen Interaction -Systems Ecology and Evolution