预防性光疗预防早产儿黄疸的有效性和安全性:系统回顾和荟萃分析。

IF 1.3 4区 医学 Q3 NURSING
Luis A Lovera, Javier Torres, Herney A García-Perdomo
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引用次数: 1

摘要

目的:比较预防性光疗与常规光疗预防新生儿黄疸的有效性和安全性。我们纳入了比较预防性光疗和常规光疗预防早产儿黄疸的临床试验。我们搜索了Embase、MEDLINE、LILACS、Central等。在RevMan (Review Manager 5.3)软件中进行统计分析。结果根据变量类型进行分析:风险差异(RD)和平均差异(MD)。由于异质性,采用随机效应模型。我们报告了森林样地的结果。评估偏倚风险,并进行敏感性分析。共发现1127篇文章,6项研究(2332例患者)纳入meta分析。5项研究将换血需求评估为主要结局(RD -0.01, 95% CI[-0.05至0.03])。一项研究评估胆红素脑病RD为-0.04,95% CI[-0.09至0.00]。5项研究评估光疗持续时间,MD为38.47,95% CI[1.28 ~ 55.67]。四项研究评估了胆红素水平(MD -1.23, 95% CI[-2.25至-0.21])。两项研究评估死亡率,相对危险度为0.01,95% CI[-0.03 ~ 0.04]。综上所述,与常规光疗相比,预防性光疗降低了最后测量的胆红素水平,以及神经发育障碍的可能性。然而,它增加了光疗时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effectiveness and safety of prophylactic phototherapy to prevent jaundice in premature newborns: Systematic review and meta-analysis.

To determine the effectiveness and safety of prophylactic phototherapy compared with conventional phototherapy for the prevention of neonatal jaundice. We included clinical trials comparing prophylactic phototherapy to conventional phototherapy to prevent jaundice in premature newborns. We searched Embase, MEDLINE, LILACS, Central, and others. The statistical analysis was performed in RevMan (Review Manager 5.3). Outcomes were analyzed according to the type of variable: risk difference (RD) and mean difference (MD). A random effects model was used due to heterogeneity. We reported results in forest plots. Risk of bias was evaluated, and a sensitivity analysis was made. 1127 articles were found, and six studies (2332 patients) were included in the meta-analysis. Five studies evaluated the need for exchange transfusion as the primary outcome RD -0.01, 95% CI [-0.05 to 0.03]. One study evaluated bilirubin encephalopathy RD -0.04, 95% CI [-0.09 to 0.00]. Five studies evaluated the duration of phototherapy, MD 38.47, 95% CI [1.28 to 55.67]. Four studies evaluated levels of bilirubin (MD -1.23, 95% CI [-2.25 to -0.21]. Two studies evaluated mortality, RD 0.01, 95% CI [-0.03 to 0.04]. As a conclusion, compared to conventional phototherapy, prophylactic phototherapy decreases the last measured level of bilirubin, as well as the probability of neurodevelopmental disturbances. However, it increases phototherapy duration.

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来源期刊
Journal of Child Health Care
Journal of Child Health Care NURSING-PEDIATRICS
CiteScore
4.10
自引率
15.80%
发文量
60
审稿时长
>12 weeks
期刊介绍: Journal of Child Health Care is a broad ranging, international, professionally-oriented, interdisciplinary and peer reviewed journal. It focuses on issues related to the health and health care of neonates, children, young people and their families, including areas such as illness, disability, complex needs, well-being, quality of life and mental health care in a diverse range of settings. The Journal of Child Health Care publishes original theoretical, empirical and review papers which have application to a wide variety of disciplines.
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