促肾上腺皮质激素释放激素基因编码区DNA甲基化与精神分裂症谱系障碍的性别依赖关联。

IF 1.2 4区医学 Q2 ANTHROPOLOGY

Annals of Human Biology Pub Date : 2023-02-01 DOI:10.1080/03014460.2023.2212176

Lili Qing, Peng Xiong, Yumei Lu, Hongyan Jiang, Shengjie Nie

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引用次数: 0

摘要

背景:精神分裂症谱系障碍(SSD)是一种常见的精神障碍，可导致严重和慢性残疾。下丘脑-垂体-肾上腺(HPA)轴相关基因的表观遗传改变被认为在SSD发病中起重要作用。促肾上腺皮质激素释放激素(CRH)基因是HPA轴的中心，在SSD患者中尚未研究其甲基化状态。目的:我们利用SSD患者外周血样本研究CRH基因编码区的甲基化状态(以下简称CRH甲基化)。对象和方法:我们收集了70例有阳性症状的SSD患者和68例健康对照者的外周血样本，用亚硫酸氢钠和甲基靶测定CRH甲基化。结果:SSD患者CRH甲基化明显升高，尤其是男性患者。结论:SSD患者外周血中可检测到CRH甲基化的差异。CRH基因的表观遗传异常与SSD的阳性症状密切相关，提示表观遗传过程可能介导SSD的病理生理。

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Sex-dependent association of DNA methylation in the coding region of the corticotropin-releasing hormone gene and schizophrenia spectrum disorder.

Background: Schizophrenia spectrum disorder (SSD) is a common mental disorder causing severe and chronic disability. Epigenetic changes in genes related to the hypothalamic-pituitary-adrenal (HPA) axis are believed to play an important role in SSD pathogenesis. The methylation status of the corticotropin-releasing hormone (CRH) gene, which is central to the HPA axis, has not been investigated in patients with SSD.

Aim: We investigated the methylation status of the coding region of the CRH gene (hereafter, CRH methylation) using peripheral blood samples from patients with SSD.

Subjects and methods: We used sodium bisulphite and MethylTarget to determine CRH methylation after collecting peripheral blood samples from 70 patients with SSD who had positive symptoms and 68 healthy controls.

Results: CRH methylation was significantly increased in patients with SSD, especially in male patients.

Conclusions: Differences in CRH methylation were detectable in the peripheral blood of patients with SSD. Epigenetic abnormalities in the CRH gene were closely related to positive symptoms of SSD, suggesting that epigenetic processes may mediate the pathophysiology of SSD.

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来源期刊

Annals of Human Biology 生物-公共卫生、环境卫生与职业卫生

CiteScore

3.40

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.