免疫组化标记在泌尿生殖系统病理挑战性诊断中的应用和陷阱。

IF 3.7 3区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY
Jianhong Li, Myra L Wilkerson, Fang-Ming Deng, Haiyan Liu
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引用次数: 0

摘要

背景泌尿生殖系统病理学中不同实体的形态特征相互重叠,给诊断带来了挑战,尤其是在诊断材料有限的情况下。当仅有形态特征不足以明确诊断时,免疫组化标记物就很有价值。世界卫生组织的泌尿系统和男性生殖器肿瘤分类已于 2022 年更新。需要对新分类的泌尿生殖系统肿瘤及其鉴别诊断的免疫组化标记物进行最新回顾:综述用于诊断肾脏、膀胱、前列腺和睾丸泌尿生殖系统病变的免疫组化标记物。我们特别强调了鉴别诊断的难点以及免疫组化应用和解释中的误区。回顾了世界卫生组织 2022 年泌尿生殖系统肿瘤分类中的新标记物和新实体。讨论了针对常见的疑难鉴别诊断和潜在陷阱推荐的染色板:数据来源:对当前文献和我们自身经验的回顾:免疫组化是诊断泌尿生殖道疑难病变的重要工具。但是,必须结合形态学结果仔细解释免疫标记,并充分了解其误区和局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Application and Pitfalls of Immunohistochemical Markers in Challenging Diagnosis of Genitourinary Pathology.

Context.—: The morphologic features of different entities in genitourinary pathology overlap, presenting a diagnostic challenge, especially when diagnostic materials are limited. Immunohistochemical markers are valuable when morphologic features alone are insufficient for definitive diagnosis. The World Health Organization classification of urinary and male genital tumors has been updated for 2022. An updated review of immunohistochemical markers for newly classified genitourinary neoplasms and their differential diagnosis is needed.

Objective.—: To review immunohistochemical markers used in the diagnosis of genitourinary lesions in the kidney, bladder, prostate, and testis. We particularly emphasized difficult differential diagnosis and pitfalls in immunohistochemistry application and interpretation. New markers and new entities in the 2022 World Health Organization classifications of genitourinary tumors are reviewed. Recommended staining panels for commonly encountered difficult differential diagnoses and potential pitfalls are discussed.

Data sources.—: Review of current literature and our own experience.

Conclusions.—: Immunohistochemistry is a valuable tool in the diagnosis of problematic lesions of the genitourinary tract. However, the immunostains must be carefully interpreted in the context of morphologic findings with a thorough knowledge of pitfalls and limitations.

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来源期刊
CiteScore
9.20
自引率
2.20%
发文量
369
审稿时长
3-8 weeks
期刊介绍: Welcome to the website of the Archives of Pathology & Laboratory Medicine (APLM). This monthly, peer-reviewed journal of the College of American Pathologists offers global reach and highest measured readership among pathology journals. Published since 1926, ARCHIVES was voted in 2009 the only pathology journal among the top 100 most influential journals of the past 100 years by the BioMedical and Life Sciences Division of the Special Libraries Association. Online access to the full-text and PDF files of APLM articles is free.
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