电磁场在创伤性脑损伤中的细胞机制。

Imran Siddiqi, Maxwell Marino, Devendra K Agrawal, Dave Baron, David A Connett, Daniel Miulli
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引用次数: 4

摘要

本文全面回顾了1980年至2023年有关电磁场(EMF)在治疗脑外伤和疾病引起的脑神经病理学中的作用和效用的现有文献。事故、伤害和疾病造成的脑创伤是造成短期和长期发病率的一个重要因素,也是全球死亡的一个主要原因。迄今为止,有限的有效治疗策略存在,主要集中在症状缓解,而不是恢复初级损伤前的功能和结构。目前的临床文献大多基于回顾性病例报告和有限的动物模型前瞻性试验,探索核心病因和损伤后临床表型的改变。目前在科学文献中报道的发现表明,电磁疗法可能有望成为创伤性脑损伤和神经病理学的潜在非侵入性治疗方法。虽然有希望,但需要精心设计的临床试验来更好地确定其在不同患者群体中的潜在临床效果。未来的试验将需要确定临床变量的影响,如性别、年龄、损伤和病理的类型和程度、损伤前的基线健康状况和全面的生物心理社会评估,以确定更有效的个性化患者护理方法。尽管最初显示出希望,但还有很多工作要做。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cellular Mechanisms of Electromagnetic Field in Traumatic Brain Injury.

Cellular Mechanisms of Electromagnetic Field in Traumatic Brain Injury.

This paper presents a comprehensive review of the extant literature from 1980 through 2023 on the role and utility of Electromagnetic Fields (EMF) in the treatment of brain trauma and brain neuropathology resulting from disease. Brain trauma resulting from accident, injury and disease is a significant contributor to short and long-term morbidity, as well as a leading cause of mortality globally. To date, limited effective treatments strategies exist, and are focused primarily on symptom relief, not restoring primary preinjury function and structure. Much of the current clinical literature is based on retrospective case reports and limited animal model prospective trials exploring core etiology and alterations in post-injury clinical phenotypes. The current findings reported in the scientific literature suggest that electromagnetic therapy may hold promise as a potential non-invasive treatment for traumatic brain injury and neuropathology. Although promising, well designed clinical trials are needed to better determine its potential clinical effectiveness in this diverse patient population. Future trials will need to determine the impact of clinical variables, such as sex, age, type and extent of injury and pathology, pre-injury baseline health status and a comprehensive biopsychosocial assessment to determine a more effective personalized approach to patient care. Although initially showing promise, much work needs to be done.

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