早产加速了视觉皮层自发和静息活动的成熟。

IF 2.6 3区 医学 Q2 BEHAVIORAL SCIENCES
Isabelle F Witteveen, Emily McCoy, Troy D Holsworth, Catherine Z Shen, Winnie Chang, Madelyn G Nance, Allison R Belkowitz, Avery Dougald, Meghan H Puglia, Adema Ribic
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引用次数: 1

摘要

早产是导致神经认知不良的主要风险之一。早产儿的大脑表现出结构和脑电活动的改变,但其潜在的回路机制尚不清楚。为了解决这个问题,我们对早产婴儿和小鼠视觉皮层的电生理活动进行了跨物种研究。通过对健康早产儿(N = 29)和足月婴儿(N = 28)的脑电图(EEG)分析,我们发现,与足月婴儿相比,早产儿非周期脑电图成分的成熟速度加快,且1/f斜率明显平坦。较平坦的坡度是由于θ和α波段的光谱功率降低,并与早熟程度相关。为了确定可能介导早产后1/f斜率变化的电路和细胞变化,我们对早产小鼠进行了体内电生理学研究,发现与婴儿相似,早产导致1/f斜率变平。我们分析了早产儿(N = 6)和足月小鼠(N = 9)视觉皮层的神经元活动,发现神经元自发放电受到抑制。利用免疫组织化学,我们进一步发现了抑制回路的加速成熟。在早产小鼠和婴儿中,皮质的功能成熟都加速了,强调出生是皮质成熟的关键检查点。我们的研究指出了与早产相关的静息神经活动变化的潜在机制,强调了跨物种方法在研究早产相关神经发育疾病的神经回路机制方面的实用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Preterm birth accelerates the maturation of spontaneous and resting activity in the visual cortex.

Preterm birth accelerates the maturation of spontaneous and resting activity in the visual cortex.

Preterm birth accelerates the maturation of spontaneous and resting activity in the visual cortex.

Preterm birth accelerates the maturation of spontaneous and resting activity in the visual cortex.

Prematurity is among the leading risks for poor neurocognitive outcomes. The brains of preterm infants show alterations in structure and electrical activity, but the underlying circuit mechanisms are unclear. To address this, we performed a cross-species study of the electrophysiological activity in the visual cortices of prematurely born infants and mice. Using electroencephalography (EEG) in a sample of healthy preterm (N = 29) and term (N = 28) infants, we found that the maturation of the aperiodic EEG component was accelerated in the preterm cohort, with a significantly flatter 1/f slope when compared to the term infants. The flatter slope was a result of decreased spectral power in the theta and alpha bands and was correlated with the degree of prematurity. To determine the circuit and cellular changes that potentially mediate the changes in 1/f slope after preterm birth, we used in vivo electrophysiology in preterm mice and found that, similar to infants, preterm birth results in a flattened 1/f slope. We analyzed neuronal activity in the visual cortex of preterm (N = 6) and term (N = 9) mice and found suppressed spontaneous firing of neurons. Using immunohistochemistry, we further found an accelerated maturation of inhibitory circuits. In both preterm mice and infants, the functional maturation of the cortex was accelerated, underscoring birth as a critical checkpoint in cortical maturation. Our study points to a potential mechanism of preterm birth-related changes in resting neural activity, highlighting the utility of a cross-species approach in studying the neural circuit mechanisms of preterm birth-related neurodevelopmental conditions.

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来源期刊
Frontiers in Integrative Neuroscience
Frontiers in Integrative Neuroscience Neuroscience-Cellular and Molecular Neuroscience
CiteScore
4.60
自引率
2.90%
发文量
148
审稿时长
14 weeks
期刊介绍: Frontiers in Integrative Neuroscience publishes rigorously peer-reviewed research that synthesizes multiple facets of brain structure and function, to better understand how multiple diverse functions are integrated to produce complex behaviors. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Our goal is to publish research related to furthering the understanding of the integrative mechanisms underlying brain functioning across one or more interacting levels of neural organization. In most real life experiences, sensory inputs from several modalities converge and interact in a manner that influences perception and actions generating purposeful and social behaviors. The journal is therefore focused on the primary questions of how multiple sensory, cognitive and emotional processes merge to produce coordinated complex behavior. It is questions such as this that cannot be answered at a single level – an ion channel, a neuron or a synapse – that we wish to focus on. In Frontiers in Integrative Neuroscience we welcome in vitro or in vivo investigations across the molecular, cellular, and systems and behavioral level. Research in any species and at any stage of development and aging that are focused at understanding integration mechanisms underlying emergent properties of the brain and behavior are welcome.
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