1990年至2021年期间中低收入国家艾滋病毒和脑血管疾病的趋势和临床特征

IF 3.7 2区医学 Q2 INFECTIOUS DISEASES

Current HIV/AIDS Reports Pub Date : 2022-12-01 DOI:10.1007/s11904-022-00627-9

George Ransley, Stanley Zimba, Yohane Gadama, Deanna Saylor, Laura Benjamin

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引用次数: 2

摘要

综述的目的:描述1990年至2021年间中低收入国家艾滋病毒和脑血管疾病的趋势和临床特征，并确定我们认识上的差距。最新发现:在抗逆转录病毒治疗(ART)时代，艾滋病毒感染者(PLWH)寿命更长，由于衰老和艾滋病毒驱动因素，脑血管事件风险增加。尽管中低收入国家的艾滋病毒感染负担最高，但这一人群的脑血管事件文献报道不足。我们系统地回顾了已发表的关于中低收入国家成人PLWH和脑血管疾病的初步临床研究的文献。在过去的三十年中，低收入国家的PLWH患者的脑血管疾病临床表型发生了演变，并向脑血管危险因素重叠的老年人群过渡。有必要增加对这一人群的研究，并使报告标准化，以促进理解，指导制定适当的干预措施，并评估其影响。

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Trends and Clinical Characteristics of HIV and Cerebrovascular Disease in Low- and Middle-Income Countries (LMICs) Between 1990 and 2021.

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Trends and Clinical Characteristics of HIV and Cerebrovascular Disease in Low- and Middle-Income Countries (LMICs) Between 1990 and 2021.

Purpose of the review: To describe trends and clinical characteristics of HIV and cerebrovascular disease between 1990 and 2021 in LMICs and identify the gaps in our understanding.

Recent findings: In the era of antiretroviral therapy (ART), people living with HIV (PLWH) live longer and risk excess cerebrovascular events due to ageing and HIV-driven factors. Despite the highest burden of HIV infection in low-to-middle income countries, there is underreporting in the literature of cerebrovascular events in this population. We systematically reviewed published literature for primary clinical studies in adult PLWH and cerebrovascular disease in LMICs. The clinical phenotype of cerebrovascular disease among PLWH over the last three decades in LMICs has evolved and transitioned to an older group with overlapping cerebrovascular risk factors. There is an important need to increase research in this population and standardise reporting to facilitate understanding, guide development of appropriate interventions, and evaluate their impact.

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来源期刊

Current HIV/AIDS Reports INFECTIOUS DISEASES-

CiteScore

8.10

自引率

2.20%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of HIV/AIDS. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antiretroviral therapies, behavioral aspects of management, and metabolic complications and comorbidity. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.