隔日禁食诱导雄性大鼠胃肠道代谢和形态功能的改变。

IF 2.4 4区 医学 Q3 NUTRITION & DIETETICS
Ana Paula Simões Beckmann, Loyane Almeida Gama, Mariana Pirani Rocha Machado, Wellington David Luz Alves, Luciana Aparecida Corá, Madileine Francely Américo
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引用次数: 1

摘要

隔日禁食(ADF)是一种具有调节和整体保护作用的营养干预措施,但其在胃肠道中的作用仍不确定。本研究旨在探讨ADF对大鼠胃肠道代谢模式和形态功能运动的影响。将32只雄性Wistar大鼠分为各组:对照组15 d (CON 15, n = 8)、对照组30 d (CON 30, n = 8)、ADF组15 d (ADF 15, n = 8)、ADF组30 d (ADF 30, n = 8),测定血糖、体重、摄食量和饮水量。测量胃收缩的频率和幅度以及胃排空时间、小肠运输时间和盲肠到达时间。肠组织形态学、器官相对重量、血脂图和瘦素水平也进行了评估。ADF减少了水的消耗和食物的消耗。体重增加减少;但相对肾脏重量增加。ADF引起胃收缩幅度增加,胃排空加速。然而,两个ADF组的小肠运输时间都延迟。ADF后,总胆固醇、甘油三酯、非高密度脂蛋白胆固醇和极低密度脂蛋白胆固醇水平下降,而绒毛高度、隐窝深度和肠环形和纵向肌层厚度增加。总之,我们的研究结果表明,ADF对代谢和胃肠道运动均有影响,并影响整体消化功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alternate-day fasting induces metabolic and morphofunctional changes in the gastrointestinal tract of male rats.

Alternate-day fasting (ADF) is a nutritional intervention with modulatory and overall protective effects, but its role in the gastrointestinal (GI) tract is still uncertain. The aim of this study was to investigate the influence of ADF on the metabolic patterns and morphofunctional motility of the GI tract in rats. Thirty-two male Wistar rats were allocated into groups: control for 15 days (CON 15, n = 8), control for 30 days (CON 30, n = 8), ADF for 15 days (ADF 15, n = 8), and ADF for 30 days (ADF 30, n = 8). Blood glucose, body weight, and food and water consumption were measured. Frequency and amplitude of gastric contractions as well as gastric emptying time, small intestinal transit time, and cecum arrival time were measured. Intestinal histomorphometric, relative weight of organs, lipidogram, and leptin levels were also evaluated. ADF decreased water consumption and food consumption. The weight gain decreased; however, the relative kidney weight increased. ADF triggered an increase in the amplitude of gastric contractions and accelerated gastric emptying. However, small intestinal transit time was delayed in both ADF groups. Total cholesterol, triglycerides, non-HDL cholesterol, and very low-density lipoprotein cholesterol levels decreased, whereas villus height, depth of the crypts and thickness of the circular, and longitudinal muscular layers of intestine increased after ADF. In conclusion, our results showed ADF exert an effect on both metabolism and GI motility and impacts on overall digestive functions.

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来源期刊
CiteScore
6.50
自引率
2.90%
发文量
113
审稿时长
4-8 weeks
期刊介绍: Applied Physiology, Nutrition, and Metabolism publishes original research articles, reviews, and commentaries, focussing on the application of physiology, nutrition, and metabolism to the study of human health, physical activity, and fitness. The published research, reviews, and symposia will be of interest to exercise physiologists, physical fitness and exercise rehabilitation specialists, public health and health care professionals, as well as basic and applied physiologists, nutritionists, and biochemists.
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