冷冻干燥同种异体骨移植物的牙槽嵴保存程序:队列研究的组织学结果。

IF 1.3 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
Giovanna Iezzi, Nicola Alberto Valente, Eugenio Velasco-Ortega, Adriano Piattelli, Alexandre Perez, Emira D'amico, Antonio Barone
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引用次数: 0

摘要

本研究的主要目的是评估在特定感兴趣区域(ROI)愈合3个月后,用冷冻干燥同种异体骨(FDBA)移植并用胶原膜密封的提取套的组织形态学结果。次要目的是分析与市售FDBA颗粒相比的生物材料吸收率、骨与生物材料的接触(BBC)以及移植颗粒的面积和周长。15名患者接受了用FDBA和胶原膜进行的拔牙和嵴保存手术。植入3个月后采集骨活检样本,用于组织学和组织形态计量学分析。在活检样本中发现了具有不同组织学特征的两个关注区域(ROI1和ROI2);对ROI1、ROI2和市售颗粒进行分析和比较。分析了以下参数:新形成的骨、骨髓间隙、残余移植物颗粒、FDBA颗粒的周长和面积以及BBC。组织形态计量学分析显示,35.22%±10.79%的新生骨、52.55%±16.06%的骨髓间隙和12.41%±7.87%的残余移植物颗粒。此外,ROI1和ROI2的组织学数据显示:(1)BBC的平均百分比为64.61%±27.14%;(2) 新形成的骨在ROI1中显著高于在ROI2中;(3) ROI1的骨髓间隙显著低于ROI2;和(4)与市售FDBA颗粒相比,ROI1位点中的FDBA颗粒显示出显著更低的面积和周长。后一个数据导致了嵌入新形成的骨中的FDBA颗粒经历吸收/重塑过程的假设。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alveolar Ridge Preservation Procedures Performed with a Freeze-Dried Bone Allograft: Histologic Outcomes in a Cohort Study.

The primary aim of this study was to assess the histomorphometric outcomes of extraction sockets grafted with freeze-dried bone allograft (FDBA) and sealed with a collagen membrane after 3 months of healing in specific region of interest (ROI) areas. The secondary aims were to analyze the biomaterial resorption rate, the bone-to-biomaterial contact (BBC), and the area and perimeter of grafted particles compared with commercially available FDBA particles. Fifteen patients underwent tooth extractions and ridge preservation procedures performed with FDBA and a collagen membrane. Bone biopsy samples were harvested after 3 months at the time of implant placement for histologic and histomorphometric analysis. Two areas of concern (ROI1 and ROI2) with different histologic features were identified within the biopsy samples; ROI1, ROI2, and commercially available particles were analyzed and compared. The following parameters were analyzed: newly formed bone, marrow space, residual graft particles, perimeter and area of FDBA particles, and BBC. The histomorphometric analysis showed 35.22% ± 10.79% newly formed bone, 52.55% ± 16.06% marrow spaces, and 12.41% ± 7.87% residual graft particles. Moreover, the histologic data from ROI1 and ROI2 showed that (1) the mean percentage of BBC was 64.61% ± 27.14%; (2) the newly formed bone was significantly higher in ROI1 than in ROI2; (3) the marrow space was significantly lower in ROI1 than in ROI2; and (4) the FDBA particles in ROI1 sites showed significantly lower area and perimeter when compared to commercially available FDBA particles. This latter data led to the hypothesis that FDBA particles embedded in newly formed bone undergo a resorption/remodeling process.

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来源期刊
CiteScore
2.90
自引率
6.20%
发文量
113
审稿时长
6-12 weeks
期刊介绍: The International Journal of Periodontics & Restorative Dentistry will publish manuscripts concerned with all aspects of clinical periodontology, restorative dentistry, and implantology. This includes pertinent research as well as clinical methodology (their interdependence and relationship should be addressed where applicable); proceedings of relevant symposia or conferences; and quality review papers. Original manuscripts are considered for publication on the condition that they have not been published or submitted for publication elsewhere.
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