淋巴细胞计数和血红蛋白对HIV患者CD4水平的预测价值。

IF 0.8 4区医学 Q4 IMMUNOLOGY

Current HIV Research Pub Date : 2023-01-01 DOI:10.2174/1570162X21666221222104349

Zheng-Rong Gao, Zheng Yuan, Chang-Song Zhao, Ru-Gang Zhao, Qiang Zhang

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引用次数: 0

摘要

目的：HIV患者易感染，治疗困难，主要表现为体内CD4+T细胞减少。因此，在前瞻性研究中讨论了淋巴细胞计数和血红蛋白对HIV患者CD4+水平的预测价值。方法：招募125名HIV患者（年龄＞18岁或＜80岁）。采用Pearson卡方检验探讨HIV患者CD4+含量与血液相关参数的相关性。单变量和多变量逻辑回归分析用于计算每个变量的OR。此外，还构建了受试者ROC曲线，以评估每个因素在诊断CD4+方面的准确性和敏感性。结果：淋巴细胞计数和血红蛋白与CD4+呈显著相关。就多变量逻辑回归水平而言，HIV患者的淋巴细胞计数（OR=3.170，95%CI:1.442-6.969，P=0.004）、血红蛋白（OR=2.545，95%CI:1.148-5.646，P=0.022）和CD4+含量之间存在显著相关性。基于神经网络模型，淋巴细胞和血红蛋白水平可能是CD4+水平的预测指标。我们发现CD4+水平的高危预警指标：3<淋巴细胞（109/L）<3.6，150<血红蛋白（g/L）<200。结论：淋巴细胞计数和血红蛋白对HIV患者CD4+水平有较好的预测价值。

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Better Predictive Value of Lymphocyte Count and Hemoglobin for CD4 Level of HIV Patients.

Objective: HIV patients are prone to infection and difficult to treat, which mainly manifests itself in decreased CD4⁺ T cells in the body. Therefore, the predictive value of lymphocyte count and hemoglobin for CD4⁺ levels in HIV patients was discussed in the prospective study.

Methods: 125 HIV patients (aged >18 or < 80 years) were recruited. Pearson chi-square test was used to explore the correlation between CD4⁺ content and blood-related parameters in HIV patients. Univariate and multivariate logistic regression analyses were used to calculate ORs for each variable. In addition, receiver ROC curves were constructed to assess each factor's accuracy and sensitivity in diagnosing CD4⁺.

Results: Lymphocyte count and hemoglobin were significantly correlated with CD4⁺. In terms of multivariate logistic regression level, there was a significant correlation between lymphocyte count (OR = 3.170, 95% CI: 1.442-6.969, P = 0.004), hemoglobin (OR = 2.545, 95% CI: 1.148- 5.646, P = 0.022) and CD4⁺ content in HIV patients. Based on the neural network model, the level of lymphocyte and hemoglobin might be the predictive indexes of CD4⁺ level. We find the high-risk warning indicator of CD4⁺ level: 3 < lymphocyte (10⁹/L) < 3.6, and 150 < hemoglobin (g/L) < 200.

Conclusion: Better predictive value of lymphocyte count and hemoglobin for CD4⁺ level of HIV patients.

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来源期刊

Current HIV Research 医学-病毒学

CiteScore

1.90

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current HIV Research covers all the latest and outstanding developments of HIV research by publishing original research, review articles and guest edited thematic issues. The novel pioneering work in the basic and clinical fields on all areas of HIV research covers: virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and transmission, anti-retroviral therapy and adherence, drug discovery, the latest developments in HIV/AIDS vaccines and animal models, mechanisms and interactions with AIDS related diseases, social and public health issues related to HIV disease, and prevention of viral infection. Periodically, the journal invites guest editors to devote an issue on a particular area of HIV research of great interest that increases our understanding of the virus and its complex interaction with the host.