用DXA和QCT评估成年1型糖尿病患者的骨密度。

IF 3.6 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Research Pub Date : 2023-01-01 DOI:10.1155/2023/8925956

Eleftheria Barmpa, Spyridon Karamagkiolis, Stelios Tigas, Parthena Navrozidou, Marianna Vlychou, Ioannis Fezoulidis, Georgios N Koukoulis, Alexandra Bargiota

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引用次数: 0

摘要

目的:采用双x线吸收仪(DXA)和定量计算机断层扫描(QCT)测量无并发症的年轻1型糖尿病(T1DM)患者和性别和年龄匹配的对照组的骨密度(BMD)，探讨其检测这些患者异常值的诊断能力。方法:118例T1DM患者(女性65例，平均年龄30.12±8.78岁)和94例性别、年龄相匹配的对照组。通过DXA和QCT在腰椎(LS)评估所有参与者的骨密度。测定骨代谢的生化指标。结果:与性别和年龄匹配的对照组相比，T1DM与DXA和QCT测量的L1-L3椎骨骨密度较低以及骨转化率较低有关。在T1DM受试者中，与DXA相比，QCT检测到的骨密度值异常患者更多。BMI和HbA1c水平是BMD的唯一决定因素。糖尿病病程越长，骨转换指标越低。结论:与DXA相比，QCT在检测无并发症T1DM患者的异常BMD值方面具有更高的灵敏度。在这些患者中，糖尿病相关的骨密度下降可能在DXA检测到之前就已经出现，DXA是骨密度测量的临床金标准，并且在出现任何其他糖尿病并发症之前就已经出现，这强调了早期干预对预防骨折的重要性。

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Bone Mineral Density in Adult Patients with Type 1 Diabetes Mellitus Assessed by Both DXA and QCT.

Purpose: Bone mineral density (BMD) was measured in uncomplicated young adult patients with type 1 diabetes mellitus (T1DM) and sex- and age-matched controls, using both dual X-ray absorptiometry (DXA) and quantitative computed tomography (QCT) to investigate their diagnostic ability in detecting abnormal values in these patients.

Methods: 118 patients with T1DM (65 females, mean age 30.12 ± 8.78 years) and 94 sex- and age-matched controls were studied. BMD was assessed in all participants by DXA and QCT at lumbar spine (LS). Biochemical markers of bone metabolism were also measured.

Results: T1DM was associated with lower BMD at L1-L3 vertebrae measured by both DXA and QCT and lower bone turnover compared to sex- and age-matched controls. In T1DM subjects, QCT detected more patients with abnormal BMD values compared to DXA. BMI and HbA1c levels were the only determinants of BMD. Bone turnover markers were lower in patients with longer duration of diabetes.

Conclusion: QCT provides a higher sensitivity compared to DXA in detecting abnormal BMD values in patients with uncomplicated T1DM. In these patients, the diabetes-related decreased BMD may be present early, before it is detected by DXA, the clinical gold standard for BMD measurements, and before the presence of any other diabetes complications, stressing the importance of an early intervention for fracture prevention.

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来源期刊

Journal of Diabetes Research ENDOCRINOLOGY & METABOLISM-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

8.40

自引率

2.30%

发文量

152

审稿时长

14 weeks

期刊介绍： Journal of Diabetes Research is a peer-reviewed, Open Access journal that publishes research articles, review articles, and clinical studies related to type 1 and type 2 diabetes. The journal welcomes submissions focusing on the epidemiology, etiology, pathogenesis, management, and prevention of diabetes, as well as associated complications, such as diabetic retinopathy, neuropathy and nephropathy.