白芨(Bletilla striata)的代谢物化学成分Reichb。f.内生真菌:草青霉。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.1080/12298093.2023.2216944

Ran Liu, Xuehua Han, Jing Gao, Min Luo, Dale Guo, Guangzhi Wang

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引用次数: 0

摘要

草酸青霉可以从白芨(Bletilla striata, Thunb)中分离得到。Reichb。f .块茎。其固态发酵产物采用渗透萃取法浓缩。采用制备高效液相色谱法对乙酸乙酯提取物进行分离纯化。基于光谱法的使用,我们已经确定17个已知化合物,12日13-dihydroxy-fumitremorgin C (1) pseurotin(2),酪醇(3),三轮车——(L-Pro-L-Val) (4), cis-4-hydroxy-8-O-methylmellein(5),尿嘧啶(6),三轮车——(L-Pro-L-Ala) (7), 1, 2, 3, 4-tetrahydro-4-hydroxy-4-quinolin羧酸(8),三轮车——(Gly-L-Pro)(9), 2的脱氧尿苷(10),1 -(β-D-ribofuranosyl)胸腺嘧啶(11),三轮车——(L-Val-Gly)(12), 2》脱氧胸苷(13),三轮车——(Gly-D-Phe) (14), cyclo-L——(4-hydroxyprolinyl) -D-leucine (15),三轮车- (L) 4-hydroxy-pro (L)板式换热器(16),尿苷(17)。本文报道了化合物1-3、5、7-8、11-12、14-17首次从该内生菌中分离得到。

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Metabolite Chemical Composition of the Bletilla striata (Thunb.) Reichb. f. Endophyte Penicillium oxalicum.

Penicillium oxalicum strain can be isolated from the Bletilla striata (Thunb.) Reichb. f. tubers. Its solid-state fermentation products are concentrated by percolation extraction. Separation and purification have been conducted to the ethyl acetate extracts by preparative HPLC. Based on the use of spectrometry, we have determined 17 known compounds, 12,13-dihydroxy-fumitremorgin C (1), pseurotin A (2), tyrosol (3), cyclo-(L-Pro-L-Val) (4), cis-4-hydroxy-8-O-methylmellein (5), uracil (6), cyclo-(L-Pro-L-Ala) (7), 1,2,3,4-tetrahydro-4-hydroxy-4-quinolin carboxylic acid (8), cyclo-(Gly-L-Pro) (9), 2'-deoxyuridine (10), 1-(β-D-ribofuranosyl)thymine (11), cyclo-(L-Val-Gly) (12), 2'-deoxythymidine (13), cyclo-(Gly-D-Phe) (14), cyclo-L-(4-hydroxyprolinyl)-D-leucine (15), cyclo-(L)-4-hydroxy-Pro-(L)-Phe (16), uridine (17). Here, we report compounds 1-3, 5, 7-8, 11-12, 14-17 are first found and isolated from this endophyte.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.