监测衰老和痴呆中的聚集蛋白和纤维结构

IF 1.7 Q3 CLINICAL NEUROLOGY
Dário Trindade, Maria Cachide, Tânia Soares Martins, Sandra Guedes, Ilka M. Rosa, Odete A.B. da Cruz e Silva, Ana Gabriela Henriques
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引用次数: 0

摘要

目的Clusterin参与多种生理过程,包括蛋白稳定。几个聚类蛋白多态性与阿尔茨海默病的风险增加有关,阿尔茨海默病是世界上痴呆症的主要病因。在此,在一个基于初级保健的队列中分析了聚类素多态性、衰老和痴呆对人类血浆中聚类素水平的影响,并讨论了这种伴侣与原纤维结构的关系。方法对来自葡萄牙队列的64名痴呆(CDR≥1)患者和64名年龄和性别匹配的对照进行CLU rs1136000多态性的基因分型,并评估血浆簇蛋白和原纤维水平。结果痴呆组CC基因型的患病率增加,尽管没有达到显著的稳健性。CLU rs11136000 SNP没有显著改变痴呆个体的血浆聚集蛋白水平。相反,clusterin水平随着年龄的增长而下降,痴呆患者的clusterin水平甚至更高。重要的是,对照组的血浆聚集蛋白水平与原纤维结构的存在相关,而痴呆组则不然。结论本研究显示,随着年龄的增长,痴呆患者的血浆聚集蛋白显著降低,这与聚集蛋白原纤维动力学的改变有关。血浆团簇蛋白及其与原纤维结构的相关性可用于监测痴呆症随年龄的进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Monitoring clusterin and fibrillar structures in aging and dementia

Monitoring clusterin and fibrillar structures in aging and dementia

Monitoring clusterin and fibrillar structures in aging and dementia

Monitoring clusterin and fibrillar structures in aging and dementia

Objective

Clusterin is involved in a variety of physiological processes, including proteostasis. Several clusterin polymorphisms were associated with an increased risk of developing Alzheimer’s disease, the world-leading cause of dementia. Herein, the effect of a clusterin polymorphism, aging and dementia in the levels of clusterin in human plasma were analysed in a primary care-based cohort, and the association of this chaperone with fibrillar structures discussed.

Methods

64 individuals with dementia (CDR≥1) and 64 age- and sex-matched Controls from a Portuguese cohort were genotyped for CLU rs1136000 polymorphism, and the plasma levels of clusterin and fibrils were assessed.

Results

An increased prevalence of the CC genotype was observed for the dementia group, although no significant robustness was achieved. CLU rs11136000 SNP did not significantly change plasma clusterin levels in demented individuals. Instead, clusterin levels decreased with aging and even more in individuals with dementia. Importantly, plasma clusterin levels correlated with the presence of fibrillar structures in Control individuals, but not in those with dementia.

Conclusion

This study reveals a significant decrease in plasma clusterin in demented individuals with aging, which related to altered clusterin-fibrils dynamics. Potentially, plasma clusterin and its association with fibrillar structures can be used to monitor dementia progression along aging.

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来源期刊
Aging brain
Aging brain Neuroscience (General), Geriatrics and Gerontology
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