通过弥散加权MRI和18F-FDG-PET/CT评估霍奇金淋巴瘤儿童平均表观扩散系数(ADC)和最大标准摄取值(SUVmax)的相关性:可行性研究

IF 2.1 4区医学 Q3 ONCOLOGY

Radiology and Oncology Pub Date : 2023-06-01 DOI:10.2478/raon-2023-0021

Nicolas Rosbach, Sebastian Fischer, Vitali Koch, Thomas J Vogl, Konrad Bochennek, Thomas Lehrnbecher, Scherwin Mahmoudi, Leon Grünewald, Frank Grünwald, Simon Bernatz

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引用次数: 0

摘要

背景:目的是分析磁共振成像(MRI)是否可以作为(18)f -氟脱氧葡萄糖(FDG)正电子发射断层扫描/计算机断层扫描(PET/CT)治疗前组织学证实的霍奇金淋巴瘤(HL)儿童的非辐射暴露替代品。这是通过分析MRI的表观扩散系数(ADC)与FDG-PET/CT的最大标准化摄取值(SUVmax)之间的潜在相关性来完成的。患者和方法:回顾性分析17例组织学证实的HL患者(6例女性，11例男性，年龄中位数:16岁，范围:12-20岁)。患者在治疗开始前接受MRI和(18)F-FDG PET/CT检查。(18)收集F-FDG PET/CT数据及相关MRI ADC图。对于每个hl病变，两名读者独立评估SUVmax和相关的平均adc。结果:17例患者共有72个可评估的HL病变，男性和女性患者的病变数量无显著差异(男性中位数:15，范围:12-19年，女性中位数:17，范围:12-18年，p = 0.021)。MRI与PET/CT的平均间隔时间为5.9±5.3天。通过类内相关系数(ICC)评估的读者间一致性非常好(ICC = 0.98, 95% CI: 0.97-0.99)。17例患者(ROIs n = 72)的相关SUVmax与平均adc呈负相关，相关性为-0.75 (95% CI: -0.84， - -0.63, p = 0.001)。分析揭示了考试领域相关性的差异。相关的SUVmax和meanADC在颈部和胸部检查中显示出很强的相关性(颈部:-0.83,95% CI: -0.93， -0.63, p < 0.0001，胸部:-0.82,95% CI: -0.91， -0.64, p < 0.0001)，在腹部检查中显示出良好的相关性，为-0.62 (95% CI: -0.83， -0.28, p = 0.001)。结论:小儿HL病变中SUVmax与meanADC呈强负相关。根据读者之间的协议，评估似乎是可靠的。我们的研究结果表明，ADC图和meanADC有可能取代PET/CT分析儿科霍奇金淋巴瘤患者的疾病活动性。这可能有助于减少PET/CT检查的次数，减少儿童的辐射暴露。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Correlation of mean apparent diffusion coefficient (ADC) and maximal standard uptake value (SUVmax) evaluated by diffusion-weighted MRI and 18F-FDG-PET/CT in children with Hodgkin lymphoma: a feasibility study.

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Background: The objective was to analyse if magnetic resonance imaging (MRI) can act as a non-radiation exposure surrogate for (18)F-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in children with histologically confirmed Hodgkin lymphoma (HL) before treatment. This was done by analysing a potential correlation between apparent diffusion coefficient (ADC) in MRI and the maximum standardized uptake value (SUVmax) in FDG-PET/CT.

Patients and methods: Seventeen patients (six female, eleven male, median age: 16 years, range: 12-20 years) with histologically confirmed HL were retrospectively analysed. The patients underwent both MRI and (18)F-FDG PET/CT before the start of treatment. (18)F-FDG PET/CT data and correlating ADC maps in MRI were collected. For each HL-lesion two readers independently evaluated the SUVmax and correlating meanADC.

Results: The seventeen patients had a total of 72 evaluable lesions of HL and there was no significant difference in the number of lesions between male and female patients (median male: 15, range: 12-19 years, median female: 17 range: 12-18 years, p = 0.021). The mean duration between MRI and PET/CT was 5.9 ± 5.3 days. The inter-reader agreement as assessed by the intraclass correlation coefficient (ICC) was excellent (ICC = 0.98, 95% CI: 0.97-0.99). The correlated SUVmax and meanADC of all 17 patients (ROIs n = 72) showed a strong negative correlation of -0.75 (95% CI: -0.84, - -0.63, p = 0.001). Analysis revealed a difference in the correlations of the examination fields. The correlated SUVmax and meanADC showed a strong correlation at neck and thoracal examinations (neck: -0.83, 95% CI: -0.93, - -0.63, p < 0.0001, thoracal: -0.82, 95% CI: -0.91, - -0.64, p < 0.0001) and a fair correlation at abdominal examinations of -0.62 (95% CI: -0.83, - -0.28, p = 0.001).

Conclusions: SUVmax and meanADC showed a strong negative correlation in paediatric HL lesions. The assessment seemed robust according to inter-reader agreements. Our results suggest that ADC maps and meanADC have the potential to replace PET/CT in the analysis of disease activity in paediatric Hodgkin lymphoma patients. This may help reduce the number of PET/CT examinations and decrease radiation exposure to children.

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来源期刊

Radiology and Oncology ONCOLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Radiology and Oncology is a multidisciplinary journal devoted to the publishing original and high quality scientific papers and review articles, pertinent to diagnostic and interventional radiology, computerized tomography, magnetic resonance, ultrasound, nuclear medicine, radiotherapy, clinical and experimental oncology, radiobiology, medical physics and radiation protection. Therefore, the scope of the journal is to cover beside radiology the diagnostic and therapeutic aspects in oncology, which distinguishes it from other journals in the field.