Michael M Cox, Myron F Goodman, James L Keck, Antoine van Oijen, Susan T Lovett, Andrew Robinson
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引用次数: 0
摘要
当复制叉遇到模板病变时,一种结果是病变跳过,即停滞的 DNA 聚合酶瞬时停滞、脱离,然后重新顺流启动,将病变留在复制后间隙中。自复制后缺口被发现以来的 60 年间,尽管人们对其给予了极大关注,但复制后缺口的产生和修复机制仍然非常神秘。这篇综述的重点是大肠杆菌中复制后间隙的产生和修复。文中介绍了有关间隙产生的频率和机制的新信息,以及解决这些问题的新机制。在少数情况下,复制后间隙的形成似乎是在特定的基因组位置编程形成的,它们是由新的基因组元素触发的。
Generation and Repair of Postreplication Gaps in Escherichia coli.
When replication forks encounter template lesions, one result is lesion skipping, where the stalled DNA polymerase transiently stalls, disengages, and then reinitiates downstream to leave the lesion behind in a postreplication gap. Despite considerable attention in the 6 decades since postreplication gaps were discovered, the mechanisms by which postreplication gaps are generated and repaired remain highly enigmatic. This review focuses on postreplication gap generation and repair in the bacterium Escherichia coli. New information to address the frequency and mechanism of gap generation and new mechanisms for their resolution are described. There are a few instances where the formation of postreplication gaps appears to be programmed into particular genomic locations, where they are triggered by novel genomic elements.
期刊介绍:
Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.