牙周感染是血栓栓塞性疾病的危险因素吗?系统的回顾。

Q2 Dentistry
Oinam Monica Devi, Jyoti Gupta, Gurparkash Singh Chahal, Ashish Jain
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引用次数: 1

摘要

背景:静脉血栓栓塞症(VTE)是一个日益严重的健康问题,包括肺栓塞(PE)和深静脉血栓形成。由于过早死亡、发病率增加以及相关的医疗费用和住院治疗,它令人担忧。牙周炎可通过感染引起的全身炎症增加VTE的风险,从而导致高凝状态和血小板聚集。本系统综述旨在综合所有关于牙周感染是血栓栓塞性疾病的危险因素的证据。材料和方法:在PubMed(MEDLINE)、Scopus和EMBASE数据库中搜索1967年至2020年12月发表的文章。结果:在PubMed、Scopus和EMBASE搜索数据库中运行搜索策略后,检索到505篇文章。根据纳入标准,纳入三项临床研究、两个病例系列和十份病例报告进行定性分析。据报道,牙周病的存在会影响静脉血栓栓塞性疾病的发生,具有统计学意义。由于纳入/可获得的研究大多是病例系列和病例报告,因此证据的强度较弱。精心设计的纵向对照临床试验产生的证据可能有助于进一步评估这种关联的强度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Is periodontal infection a risk factor for thromboembolic disease? A systematic review.

Is periodontal infection a risk factor for thromboembolic disease? A systematic review.

Background: Venous thromboembolism (VTE) is a rising major health problem comprising pulmonary embolism (PE) and deep vein thrombosis. It is of concern due to premature mortality, increased morbidity, and associated healthcare costs and hospitalization. Periodontitis can increase the risk of VTE by way of systemic inflammation induced by infection that can contribute to hypercoagulability and platelet aggregation. This systematic review aims to synthesize all the evidence concerning periodontal infection as a risk factor for thromboembolic disease.

Materials and methods: A search for articles published from 1967 till December 2020 was conducted in the PubMed (MEDLINE), Scopus, and EMBASE data bases.

Results: Five hundred and five articles were retrieved after running search strategies in PubMed, Scopus, and EMBASE search databases. Based on the inclusion criteria, three clinical studies, two case series, and ten case reports were included for qualitative analysis. The presence of periodontal disease was reported to influence the occurrence of venous thromboembolic disease with a statistical significance of <0.010. Case series and case reports of septic PE due to periodontal disease showed complete resolution of lung lesions and subsiding of symptoms after dental treatment and antimicrobial therapy.

Conclusions: The results of this systematic review suggested for an association between periodontal disease and the incidence of thromboembolic disease. As most of the included/available studies are case series and case reports, the strength of evidence is weak. Evidence generated from well-designed longitudinal controlled clinical trials may be helpful to further assess the strength of the association.

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来源期刊
CiteScore
1.70
自引率
0.00%
发文量
87
审稿时长
44 weeks
期刊介绍: The Journal of Indian Society of Periodontology publishes original scientific articles to support practice , education and research in the dental specialty of periodontology and oral implantology. Journal of Indian Society of Periodontology (JISP), is the official publication of the Society and is managed and brought out by the Editor of the society. The journal is published Bimonthly with special issues being brought out for specific occasions. The ISP had a bulletin as its publication for a large number of years and was enhanced as a Journal a few years ago
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