Richard Heyes, Charles H Adler, Nan Zhang, David G Lott, Stephen F Bansberg
{"title":"肉毒杆菌神经毒素治疗内收肌痉挛性发音障碍的剂量与年龄和性别有关。","authors":"Richard Heyes, Charles H Adler, Nan Zhang, David G Lott, Stephen F Bansberg","doi":"10.1002/wjo2.88","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to analyze the impact of age and sex on botulinum neurotoxin (BoNT-A) dosing and outcomes in adductor spasmodic dysphonia (AdSD).</p><p><strong>Methods: </strong>A database review of all spasmodic dysphonia patients treated with BoNT from 1989 to 2018 at the Mayo Clinic in Arizona was performed. Only patients who had received ≥4 injections of BoNT-A for AdSD were included. Patients were divided into two cohorts to analyze age, with an age of first treatment cutoff of 60 years. Patients were divided into male and female cohorts to analyze sex.</p><p><strong>Results: </strong>The final analysis included 398 patients. The mean dose of BoNT-A per treatment was significantly higher in the younger cohort (4.4 vs. 3.9 units, <i>p</i> = 0.048). The mean maximal benefit was similar (72% vs. 70%, <i>p</i> = 0.48); however, the mean length of benefit was significantly shorter in younger patients (3.0 vs. 3.6 months, <i>p</i> < 0.01). The mean BoNT-A dose was significantly higher in the female cohort (4.2 vs. 3.6 units, <i>p</i> = 0.02). The mean maximal benefit was similar (69% vs. 75%, <i>p</i> = 0.58), as was the mean length of benefit (3.2 vs. 3.5 months, <i>p</i> = 0.11).</p><p><strong>Conclusions: </strong>This study suggests that age and sex influence BoNT-A dosing and outcomes in AdSD.</p>","PeriodicalId":32097,"journal":{"name":"World Journal of OtorhinolaryngologyHead and Neck Surgery","volume":"9 2","pages":"168-173"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296044/pdf/","citationCount":"0","resultStr":"{\"title\":\"Significance of age and sex in botulinum neurotoxin dosing for adductor spasmodic dysphonia.\",\"authors\":\"Richard Heyes, Charles H Adler, Nan Zhang, David G Lott, Stephen F Bansberg\",\"doi\":\"10.1002/wjo2.88\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study aims to analyze the impact of age and sex on botulinum neurotoxin (BoNT-A) dosing and outcomes in adductor spasmodic dysphonia (AdSD).</p><p><strong>Methods: </strong>A database review of all spasmodic dysphonia patients treated with BoNT from 1989 to 2018 at the Mayo Clinic in Arizona was performed. Only patients who had received ≥4 injections of BoNT-A for AdSD were included. Patients were divided into two cohorts to analyze age, with an age of first treatment cutoff of 60 years. Patients were divided into male and female cohorts to analyze sex.</p><p><strong>Results: </strong>The final analysis included 398 patients. The mean dose of BoNT-A per treatment was significantly higher in the younger cohort (4.4 vs. 3.9 units, <i>p</i> = 0.048). The mean maximal benefit was similar (72% vs. 70%, <i>p</i> = 0.48); however, the mean length of benefit was significantly shorter in younger patients (3.0 vs. 3.6 months, <i>p</i> < 0.01). The mean BoNT-A dose was significantly higher in the female cohort (4.2 vs. 3.6 units, <i>p</i> = 0.02). The mean maximal benefit was similar (69% vs. 75%, <i>p</i> = 0.58), as was the mean length of benefit (3.2 vs. 3.5 months, <i>p</i> = 0.11).</p><p><strong>Conclusions: </strong>This study suggests that age and sex influence BoNT-A dosing and outcomes in AdSD.</p>\",\"PeriodicalId\":32097,\"journal\":{\"name\":\"World Journal of OtorhinolaryngologyHead and Neck Surgery\",\"volume\":\"9 2\",\"pages\":\"168-173\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296044/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World Journal of OtorhinolaryngologyHead and Neck Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/wjo2.88\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/6/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of OtorhinolaryngologyHead and Neck Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/wjo2.88","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/6/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Significance of age and sex in botulinum neurotoxin dosing for adductor spasmodic dysphonia.
Objectives: This study aims to analyze the impact of age and sex on botulinum neurotoxin (BoNT-A) dosing and outcomes in adductor spasmodic dysphonia (AdSD).
Methods: A database review of all spasmodic dysphonia patients treated with BoNT from 1989 to 2018 at the Mayo Clinic in Arizona was performed. Only patients who had received ≥4 injections of BoNT-A for AdSD were included. Patients were divided into two cohorts to analyze age, with an age of first treatment cutoff of 60 years. Patients were divided into male and female cohorts to analyze sex.
Results: The final analysis included 398 patients. The mean dose of BoNT-A per treatment was significantly higher in the younger cohort (4.4 vs. 3.9 units, p = 0.048). The mean maximal benefit was similar (72% vs. 70%, p = 0.48); however, the mean length of benefit was significantly shorter in younger patients (3.0 vs. 3.6 months, p < 0.01). The mean BoNT-A dose was significantly higher in the female cohort (4.2 vs. 3.6 units, p = 0.02). The mean maximal benefit was similar (69% vs. 75%, p = 0.58), as was the mean length of benefit (3.2 vs. 3.5 months, p = 0.11).
Conclusions: This study suggests that age and sex influence BoNT-A dosing and outcomes in AdSD.
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