哺乳动物光感受器死亡过程中的小胶质细胞活化和炎症。

IF 5 2区医学 Q1 NEUROSCIENCES

Annual Review of Vision Science Pub Date : 2020-09-15 DOI:10.1146/annurev-vision-121219-081730

Sarah J Karlen, Eric B Miller, Marie E Burns

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引用次数: 19

摘要

光感受器是高度特化的感觉神经元，具有独特的代谢和生理需求。这些需求部分由神经胶质细胞和视网膜色素上皮细胞(RPE)满足，它们提供必需的代谢物，吞噬废物，并控制周围微环境的组成。第三种重要的支持细胞类型是视网膜小胶质细胞，它可以为光感受器提供神经营养支持或加剧神经炎症并加速神经元细胞死亡。了解光感受器稳态的生理需求以及驱动小胶质细胞最好地促进光感受器存活的因素，对治疗和预防视网膜色素变性和年龄相关性黄斑变性等致盲性退行性疾病具有重要意义。

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Microglia Activation and Inflammation During the Death of Mammalian Photoreceptors.

Photoreceptors are highly specialized sensory neurons with unique metabolic and physiological requirements. These requirements are partially met by Müller glia and cells of the retinal pigment epithelium (RPE), which provide essential metabolites, phagocytose waste, and control the composition of the surrounding microenvironment. A third vital supporting cell type, the retinal microglia, can provide photoreceptors with neurotrophic support or exacerbate neuroinflammation and hasten neuronal cell death. Understanding the physiological requirements for photoreceptor homeostasis and the factors that drive microglia to best promote photoreceptor survival has important implications for the treatment and prevention of blinding degenerative diseases like retinitis pigmentosa and age-related macular degeneration.

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来源期刊

Annual Review of Vision Science Medicine-Ophthalmology

CiteScore

11.10

自引率

1.70%

发文量

期刊介绍： The Annual Review of Vision Science reviews progress in the visual sciences, a cross-cutting set of disciplines which intersect psychology, neuroscience, computer science, cell biology and genetics, and clinical medicine. The journal covers a broad range of topics and techniques, including optics, retina, central visual processing, visual perception, eye movements, visual development, vision models, computer vision, and the mechanisms of visual disease, dysfunction, and sight restoration. The study of vision is central to progress in many areas of science, and this new journal will explore and expose the connections that link it to biology, behavior, computation, engineering, and medicine.