先天性巨细胞病毒感染与儿童急性淋巴细胞白血病的发展有关吗?

IF 5.7 2区医学 Q1 VIROLOGY

Current opinion in virology Pub Date : 2023-06-01 DOI:10.1016/j.coviro.2023.101325

Rajbir K Toor , Eleanor C Semmes , Kyle M Walsh , Sallie R Permar , Lisa Giulino-Roth

{"title":"先天性巨细胞病毒感染与儿童急性淋巴细胞白血病的发展有关吗?","authors":"Rajbir K Toor , Eleanor C Semmes , Kyle M Walsh , Sallie R Permar , Lisa Giulino-Roth","doi":"10.1016/j.coviro.2023.101325","DOIUrl":null,"url":null,"abstract":"<div><p>Cytomegalovirus (CMV) is a ubiquitous herpesvirus that has a profound impact on the host immune system. Congenital cytomegalovirus (cCMV) infection modulates neonatal immune cell compartments, yet the full impact of <em>in utero</em> exposure on developing fetal immune cells remains poorly characterized. A series of recent studies have identified a potential link between cCMV infection and the development of acute lymphoblastic leukemia (ALL) in childhood. Here, we review the emerging evidence linking CMV and ALL risk, discuss what is known about the causes of childhood ALL, and propose how CMV infection in early life may confer increased ALL risk.</p></div>","PeriodicalId":11082,"journal":{"name":"Current opinion in virology","volume":"60 ","pages":"Article 101325"},"PeriodicalIF":5.7000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Does congenital cytomegalovirus infection contribute to the development of acute lymphoblastic leukemia in children?\",\"authors\":\"Rajbir K Toor , Eleanor C Semmes , Kyle M Walsh , Sallie R Permar , Lisa Giulino-Roth\",\"doi\":\"10.1016/j.coviro.2023.101325\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Cytomegalovirus (CMV) is a ubiquitous herpesvirus that has a profound impact on the host immune system. Congenital cytomegalovirus (cCMV) infection modulates neonatal immune cell compartments, yet the full impact of <em>in utero</em> exposure on developing fetal immune cells remains poorly characterized. A series of recent studies have identified a potential link between cCMV infection and the development of acute lymphoblastic leukemia (ALL) in childhood. Here, we review the emerging evidence linking CMV and ALL risk, discuss what is known about the causes of childhood ALL, and propose how CMV infection in early life may confer increased ALL risk.</p></div>\",\"PeriodicalId\":11082,\"journal\":{\"name\":\"Current opinion in virology\",\"volume\":\"60 \",\"pages\":\"Article 101325\"},\"PeriodicalIF\":5.7000,\"publicationDate\":\"2023-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current opinion in virology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1879625723000251\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"VIROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in virology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1879625723000251","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VIROLOGY","Score":null,"Total":0}

引用次数: 1

摘要

巨细胞病毒（CMV）是一种普遍存在的疱疹病毒，对宿主免疫系统有着深远的影响。先天性巨细胞病毒（cCMV）感染调节新生儿免疫细胞区室，但子宫内暴露对发育中的胎儿免疫细胞的全面影响仍不明确。最近的一系列研究已经确定了cCMV感染与儿童急性淋巴细胞白血病（ALL）发展之间的潜在联系。在这里，我们回顾了将CMV和ALL风险联系起来的新证据，讨论了儿童ALL的已知原因，并提出了早期CMV感染如何增加ALL风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Does congenital cytomegalovirus infection contribute to the development of acute lymphoblastic leukemia in children?

Cytomegalovirus (CMV) is a ubiquitous herpesvirus that has a profound impact on the host immune system. Congenital cytomegalovirus (cCMV) infection modulates neonatal immune cell compartments, yet the full impact of in utero exposure on developing fetal immune cells remains poorly characterized. A series of recent studies have identified a potential link between cCMV infection and the development of acute lymphoblastic leukemia (ALL) in childhood. Here, we review the emerging evidence linking CMV and ALL risk, discuss what is known about the causes of childhood ALL, and propose how CMV infection in early life may confer increased ALL risk.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Current opinion in virology VIROLOGY-

CiteScore

11.80

自引率

5.10%

发文量

审稿时长

83 days

期刊介绍： Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.