Patricia Garcia, Lisandra Mendoza, Dilianna Padron, Andres Duarte, Ranjan Duara, David Loewenstein, Maria Greig-Custo, Warren Barker, Rosie Curiel, Monica Rosselli, Miriam Rodriguez
{"title":"在控制载脂蛋白E4生物标志物和人口统计学变量的影响后，性别可明显预测颞叶内侧体积：跨种族比较","authors":"Patricia Garcia, Lisandra Mendoza, Dilianna Padron, Andres Duarte, Ranjan Duara, David Loewenstein, Maria Greig-Custo, Warren Barker, Rosie Curiel, Monica Rosselli, Miriam Rodriguez","doi":"10.1017/S1355617723000358","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To explore the relationship between age, education, sex, and ApoE4 (+) status to brain volume among a cohort with amnestic mild cognitive impairment (aMCI).</p><p><strong>Method: </strong>One hundred and twenty-three participants were stratified into Hispanic (<i>n</i> = 75) and White non-Hispanic (WNH, <i>N</i> = 48). Multiple linear regression analyses were conducted with age, education, sex, and ApoE4 status as predictor variables and left and right combined MRI volumes of the hippocampus, parahippocampus, and entorhinal cortex as dependent variables. Variations in head sizes were corrected by normalization with a total intracranial volume measurement.</p><p><strong>Results: </strong>Bonferroni-corrected results indicated that when controlling for ApoE4 status, education, and age, sex was a significant predictor of hippocampal volume among the Hispanic group (<i>β</i> = .000464, <i>R</i><sup>2</sup> = .196, <i>p < .01</i>) and the WNH group (<i>β</i> = .000455, <i>R</i><sup>2</sup> = .195, <i>p < .05</i>). Education (<i>β</i> = .000028, <i>R</i><sup>2</sup> = .168, <i>p < .01</i>) and sex (<i>β</i> = .000261, <i>R</i><sup>2</sup> = .168, <i>p < .01</i>) were significant predictors of parahippocampal volume among the Hispanic MCI group when controlling for the effects of ApoE4 status and age. One-way ANCOVAs comparing hippocampal and parahippocampal volume between males and females within groups revealed that females had significantly larger hippocampal volumes (<i>p</i> < .05). Hispanic females had significantly larger hippocampal (<i>p</i> < .001) and parahippocampal (<i>p</i> < .05) volume compared to males. No sex differences in parahippocampal volume were noted among WNHs.</p><p><strong>Conclusions: </strong>Biological sex, rather than ApoE4 status, was a greater predictor of hippocampal volume among Hispanic and WNH females. These findings add to the mixed literature on sex differences in dementia research and highlight continued emphasis on ethnic populations to elucidate on neurodegenerative disparities.</p>","PeriodicalId":49995,"journal":{"name":"Journal of the International Neuropsychological Society","volume":" ","pages":"128-137"},"PeriodicalIF":2.6000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057967/pdf/","citationCount":"0","resultStr":"{\"title\":\"Sex significantly predicts medial temporal volume when controlling for the influence of ApoE4 biomarker and demographic variables: A cross-ethnic comparison.\",\"authors\":\"Patricia Garcia, Lisandra Mendoza, Dilianna Padron, Andres Duarte, Ranjan Duara, David Loewenstein, Maria Greig-Custo, Warren Barker, Rosie Curiel, Monica Rosselli, Miriam Rodriguez\",\"doi\":\"10.1017/S1355617723000358\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To explore the relationship between age, education, sex, and ApoE4 (+) status to brain volume among a cohort with amnestic mild cognitive impairment (aMCI).</p><p><strong>Method: </strong>One hundred and twenty-three participants were stratified into Hispanic (<i>n</i> = 75) and White non-Hispanic (WNH, <i>N</i> = 48). Multiple linear regression analyses were conducted with age, education, sex, and ApoE4 status as predictor variables and left and right combined MRI volumes of the hippocampus, parahippocampus, and entorhinal cortex as dependent variables. Variations in head sizes were corrected by normalization with a total intracranial volume measurement.</p><p><strong>Results: </strong>Bonferroni-corrected results indicated that when controlling for ApoE4 status, education, and age, sex was a significant predictor of hippocampal volume among the Hispanic group (<i>β</i> = .000464, <i>R</i><sup>2</sup> = .196, <i>p < .01</i>) and the WNH group (<i>β</i> = .000455, <i>R</i><sup>2</sup> = .195, <i>p < .05</i>). Education (<i>β</i> = .000028, <i>R</i><sup>2</sup> = .168, <i>p < .01</i>) and sex (<i>β</i> = .000261, <i>R</i><sup>2</sup> = .168, <i>p < .01</i>) were significant predictors of parahippocampal volume among the Hispanic MCI group when controlling for the effects of ApoE4 status and age. One-way ANCOVAs comparing hippocampal and parahippocampal volume between males and females within groups revealed that females had significantly larger hippocampal volumes (<i>p</i> < .05). Hispanic females had significantly larger hippocampal (<i>p</i> < .001) and parahippocampal (<i>p</i> < .05) volume compared to males. No sex differences in parahippocampal volume were noted among WNHs.</p><p><strong>Conclusions: </strong>Biological sex, rather than ApoE4 status, was a greater predictor of hippocampal volume among Hispanic and WNH females. These findings add to the mixed literature on sex differences in dementia research and highlight continued emphasis on ethnic populations to elucidate on neurodegenerative disparities.</p>\",\"PeriodicalId\":49995,\"journal\":{\"name\":\"Journal of the International Neuropsychological Society\",\"volume\":\" \",\"pages\":\"128-137\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057967/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the International Neuropsychological Society\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://doi.org/10.1017/S1355617723000358\",\"RegionNum\":4,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/6/30 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the International Neuropsychological Society","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1017/S1355617723000358","RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/6/30 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Sex significantly predicts medial temporal volume when controlling for the influence of ApoE4 biomarker and demographic variables: A cross-ethnic comparison.
Objective: To explore the relationship between age, education, sex, and ApoE4 (+) status to brain volume among a cohort with amnestic mild cognitive impairment (aMCI).
Method: One hundred and twenty-three participants were stratified into Hispanic (n = 75) and White non-Hispanic (WNH, N = 48). Multiple linear regression analyses were conducted with age, education, sex, and ApoE4 status as predictor variables and left and right combined MRI volumes of the hippocampus, parahippocampus, and entorhinal cortex as dependent variables. Variations in head sizes were corrected by normalization with a total intracranial volume measurement.
Results: Bonferroni-corrected results indicated that when controlling for ApoE4 status, education, and age, sex was a significant predictor of hippocampal volume among the Hispanic group (β = .000464, R2 = .196, p < .01) and the WNH group (β = .000455, R2 = .195, p < .05). Education (β = .000028, R2 = .168, p < .01) and sex (β = .000261, R2 = .168, p < .01) were significant predictors of parahippocampal volume among the Hispanic MCI group when controlling for the effects of ApoE4 status and age. One-way ANCOVAs comparing hippocampal and parahippocampal volume between males and females within groups revealed that females had significantly larger hippocampal volumes (p < .05). Hispanic females had significantly larger hippocampal (p < .001) and parahippocampal (p < .05) volume compared to males. No sex differences in parahippocampal volume were noted among WNHs.
Conclusions: Biological sex, rather than ApoE4 status, was a greater predictor of hippocampal volume among Hispanic and WNH females. These findings add to the mixed literature on sex differences in dementia research and highlight continued emphasis on ethnic populations to elucidate on neurodegenerative disparities.
期刊介绍：
The Journal of the International Neuropsychological Society is the official journal of the International Neuropsychological Society, an organization of over 4,500 international members from a variety of disciplines. The Journal of the International Neuropsychological Society welcomes original, creative, high quality research papers covering all areas of neuropsychology. The focus of articles may be primarily experimental, applied, or clinical. Contributions will broadly reflect the interest of all areas of neuropsychology, including but not limited to: development of cognitive processes, brain-behavior relationships, adult and pediatric neuropsychology, neurobehavioral syndromes (such as aphasia or apraxia), and the interfaces of neuropsychology with related areas such as behavioral neurology, neuropsychiatry, genetics, and cognitive neuroscience. Papers that utilize behavioral, neuroimaging, and electrophysiological measures are appropriate.
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