疟疾高流行区向低流行区过渡的强化疟疾控制项目影响评估:流行病学方面。

IF 4.9 4区 医学 Q1 PARASITOLOGY
Pathogens and Global Health Pub Date : 2023-07-01 Epub Date: 2023-03-24 DOI:10.1080/20477724.2023.2194498
Rahim Ali Ahmed, Avdhesh Kumar, Ananta Swargiary, Harpal Singh Suri, Hari Shankar, Syed Shah Areeb Hussain, Gaurav Kumar, Kuldeep Singh, Dipika Kalita, Afluza Begum
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引用次数: 0

摘要

强化疟疾控制项目(IMCP)于 2005 年实施,目的是在印度东北部各邦和奥迪沙邦控制疟疾。本研究旨在调查强化疟疾控制项目对减轻印度东北部阿萨姆邦乌达尔古里地区疟疾负担的影响。疟疾流行病学数据来自疟疾综合防治方案干预区(乌达尔古里)和非干预区(贾坎德邦西辛布胡米)。IMCP 活动包括在印度东北部引入双价快速诊断试剂盒 (RDT)、蒿甲醚-本芴醇(Artemether-Lumefantrine)药物、分发长效驱虫蚊帐 (LLIN),并以强化模式开展疟疾宣传计划。数据显示,2009 年使用长效驱虫蚊帐后,年寄生虫发病率(API)从 14.94(2005 年)大幅下降至 2.61(2018 年),降幅为 37%(95%CI:-57%,-19%,p = 001);在 Udalguri 地区引入 RDTs 后,降幅为 64%(95%CI:-116%,-14%,p = 013)。而对照区使用长效驱虫蚊帐的 API 下降了 -28% (95%CI: -63%, 6.3%, p = 0.051),在引入 RDT 后上升了 10% (95%CI: -7.6%, 28%, p = 0.122)。恶性疟原虫(Pf)和间日疟原虫(Pv)是乌达尔古里的主要疟疾寄生虫。在研究期间,恶性疟原虫疟疾的发病率(71%)远远高于疟原虫疟疾(29%)。在乌达尔古里,疟原虫病例呈上升趋势。Udalguri 和 Khoirabari BPHCs 的疟疾病例总体上分别减少了 94% (95%CI: -143%, -45%, p = 0.001) 和 84% (95%CI: -126%, -39%, p = 0.003);然而,在 Orang BPHC 中只观察到 API 减少了 10% (95%CI: -65%, -41%, p = 0.360)。疟疾发病率的总体下降表明乌达尔古里地区有效实施了病媒和疾病控制战略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact assessment of Intensified Malaria Control Project in transitioning a high malaria-endemic district to a low-endemic district: an epidemiological aspect.

Intensified Malaria Control Project (IMCP) was implemented in 2005 to control malaria in all North-Eastern and Odisha states of India. The present study aimed to investigate the impact of IMCP in reducing the malaria burden in Udalguri district, Assam state of North-East India. Malaria epidemiological data were obtained for IMCP intervention (Udalguri) and nonintervention district (West Singhbhumi, Jharkhand state). IMCP activities include introducing bi-valent rapid diagnostic kits (RDTs), Artemether-Lumefantrine drug in North-East India, long-lasting insecticidal nets (LLINs) distribution, and creating awareness programs about malaria in an intensified mode. The data revealed a significant decline in annual parasite incidence (API) from 14.94 (2005) to 2.61 (2018), -37% (95%CI: -57%, -19%, p = 001) after using LLINs in 2009 and -64% (95%CI: -116%, -14%, p = 013) after the introduction of RDTs in district Udalguri. Whereas control district showed a -28% (95%CI: -63%, 6.3%, p = 0.051) decrease in API using LLINs and a 10% (95%CI: -7.6%, 28%, p = 0.122) increase after the introduction of RDTs. Plasmodium falciparum (Pf) and P. vivax (Pv) were the major malarial parasites in Udalguri. Pv-malaria was much higher (71%) than Pf-malaria (29%) during the study period. An increasing trend of Pf cases was observed in Udalguri. Udalguri and Khoirabari BPHCs showed an overall reduction of 94% (95%CI: -143%, -45%, p = 0.001) and 84% (95%CI: -126%, -39%, p = 0.003), respectively; however, only a 10% (95%CI: -65%, -41%, p = 0.360) reduction in API was observed in Orang BPHC. An overall decrease in malaria indicates the effective implementation of vector and disease control strategies in the Udalguri district.

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来源期刊
Pathogens and Global Health
Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY
CiteScore
6.00
自引率
0.00%
发文量
60
审稿时长
6-12 weeks
期刊介绍: Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.
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