酵母中对 NCR 敏感基因转录的不同 SAGA 模块要求。

IF 2.2 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Yeast Pub Date : 2024-04-01 Epub Date: 2023-06-25 DOI:10.1002/yea.3885

Isabelle Georis, Aria Ronsmans, Fabienne Vierendeels, Evelyne Dubois

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引用次数: 0

摘要

氮代谢抑制（NCR）是酵母使其转录组适应环境中氮源变化的一种手段。在解除抑制的条件下（贫氮条件下、雷帕霉素处理后或谷氨酰胺生产受到抑制时），GATA 家族的两个转录激活因子被招募到对 NCR 敏感的启动子上，并激活对 NCR 敏感基因的转录。早先的观察发现，Spt-Ada-Gcn5 乙酰转移酶（SAGA）染色质重塑复合物参与了这些转录调控。在本报告中，我们对不同的 NCR 敏感反应进行了说明，并质疑不同的 SAGA 招募是否可以解释这种反应的多样性。

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Differing SAGA module requirements for NCR-sensitive gene transcription in yeast.

Nitrogen catabolite repression (NCR) is a means for yeast to adapt its transcriptome to changing nitrogen sources in its environment. In conditions of derepression (under poor nitrogen conditions, upon rapamycin treatment, or when glutamine production is inhibited), two transcriptional activators of the GATA family are recruited to NCR-sensitive promoters and activate transcription of NCR-sensitive genes. Earlier observations have involved the Spt-Ada-Gcn5 acetyltransferase (SAGA) chromatin remodeling complex in these transcriptional regulations. In this report, we provide an illustration of the varying NCR-sensitive responses and question whether differing SAGA recruitment could explain this diversity of responses.

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来源期刊

Yeast 生物-生化与分子生物学

CiteScore

5.30

自引率

3.80%

发文量

审稿时长

3 months

期刊介绍： Yeast publishes original articles and reviews on the most significant developments of research with unicellular fungi, including innovative methods of broad applicability. It is essential reading for those wishing to keep up to date with this rapidly moving field of yeast biology. Topics covered include: biochemistry and molecular biology; biodiversity and taxonomy; biotechnology; cell and developmental biology; ecology and evolution; genetics and genomics; metabolism and physiology; pathobiology; synthetic and systems biology; tools and resources