三己苯肼在幼儿张力障碍脑瘫中的作用:单臂研究。

IF 0.8 Q4 PEDIATRICS
Lavanya Rajkumar, Abhinaya Ventatakrishnan, Smitha Sairam, Megha Khosla, Ritu Khanna, Biswajit Das, Devendra Mishra, Monica Juneja
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引用次数: 0

摘要

目的:肌张力障碍脑瘫发病率呈上升趋势。儿童肌张力障碍的治疗缺乏证据。方法:选取41例6个月~ 5岁以肌张力障碍为主的脑瘫患儿,采用预先确定的三苯基(0.25 ~ 0.52 mg/kg)治疗方案,分别于3、6、12周进行随访。使用全球肌张力障碍量表(GDS)、大运动功能量表(GMFM)和早期发育概况的精细运动/知觉子量表-2比较基线和12周时肌张力障碍的严重程度、运动功能和发育年龄。34名儿童完成了整个12周的干预。结果:患者平均年龄25±11个月。干预后GDS总肌张力障碍评分中位数显著下降(74.5 - 59,p)。结论:本研究中,三苯乙烯可显著改善肌张力障碍脑瘫患儿的肌张力障碍、运动功能和发育。需要进一步的研究来阐明它在大量患有这种疾病的儿童中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Trihexyphenidyl in young children with dystonic cerebral palsy: A single arm study.

Purpose: The incidence of dystonic cerebral palsy causing significant morbidity is on the rise. There is a paucity of evidence for the management of dystonia in children.

Methods: Forty-one children aged 6 months-5 years with predominantly dystonic cerebral palsy were started on a predetermined protocol of trihexyphenidyl (0.25-0.52 mg/kg) and followed up at 3, 6 and 12 weeks. Dystonia severity, motor function and developmental age at baseline and 12 weeks were compared using the Global Dystonia Scale (GDS), the Gross Motor Function Measure (GMFM), and Fine Motor/Perceptual Subscale of the Early Developmental Profile-2. Thirty-four children completed the entire 12 weeks of intervention.

Results: The mean age of participants was 25±11 months. A significant decrease in median total dystonia scores on the GDS was observed post-intervention (74.5 to 59, p < 0.0001), and 64% of participants gained motor milestones. GMFM scores increased significantly from a median of 19.8% pre-intervention to 26.5% post-intervention (p < 0.0001). There was improvement in the fine motor domain as compared to the baseline (p < 0.0001). The number of children classified at Gross Motor Function Classification System levels 1 and 2 increased to 47.05% from 5.88% in the pre-intervention group.

Conclusion: Trihexyphenidyl significantly improved dystonia, motor function and development in children with dystonic cerebral palsy in this study. Additional studies are needed to clarify its role in larger numbers of children with this condition.

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来源期刊
CiteScore
2.30
自引率
5.30%
发文量
139
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