各种关节病变中滑液淀粉酶水平及显微层析指数的临床及病理意义。

IF 1.1 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
I N Schendrigin, L D Timchenko, I V Rzhepakovsky, S S Avanesyan, M N Sizonenko, W-D Grimm, S N Povetkin, S I Piskov
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引用次数: 6

摘要

本研究的目的是通过与反映各种关节疾病病理过程特征的已知信息指标的相关性,研究滑液密度的淀粉水解活性水平和显微层析指数,并证实其临床和病理意义。材料和方法:对95例以关节腔内大量积液为特征的不同关节病变患者的滑液样本进行了检查。通过膝关节穿刺获得的滑液样本作为研究的材料。采用常规方法测定所选样品的尿酸浓度、无机磷浓度、总蛋白浓度和解淀粉活性水平,并用计算机显微断层扫描鉴定x射线密度。结果:与健康关节的滑液相比,所有病理关节液的样品都显示出高水平的解淀粉活性。滑膜溶淀粉活性水平与特定关节病理之间的关系已被确定。还发现各种类型关节损伤的尿酸值、无机磷浓度和总蛋白可能影响滑液的x线密度。建立了所研究指标之间的相关关系。结论:在一种非炎症性疾病和六种不同的炎症性疾病中获得了滑膜解淀粉活性水平的新数据。病理确定的滑液密度显微层析指数与尿酸、无机磷、总蛋白浓度的相关性已得到证实。各种关节病变中滑膜x线密度的具体指标,以及与常规比较的单向和多向数据,使我们认为x线微断层扫描作为一种方法,可以在滑膜液密度的调查中揭示更多的细节,并为研究各种关节病变的发生、分化和治疗的发病机制带来新的替代标记。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Clinical and Pathogenetic Significance of Amylase Level and Microtomographic Index of Synovial Fluid in Various Joint Lesions.

Clinical and Pathogenetic Significance of Amylase Level and Microtomographic Index of Synovial Fluid in Various Joint Lesions.

Clinical and Pathogenetic Significance of Amylase Level and Microtomographic Index of Synovial Fluid in Various Joint Lesions.

Clinical and Pathogenetic Significance of Amylase Level and Microtomographic Index of Synovial Fluid in Various Joint Lesions.

The aim of the investigation was to study the level of amylolytic activity and microtomographic index of synovial fluid density as well as to substantiate their clinical and pathogenetic significance by identifying correlations with the known informative indicators reflecting characteristic features of the pathological process in various joint diseases.

Materials and methods: Samples of synovial fluid from 95 patients with various joint pathologies at the stage of the disease progression characterized by copious effusion into articular cavities have been examined. Synovial fluid samples obtained by knee arthrocentesis served as a material for the investigation. Conventional methods were used to determine the concentration of uric acid, inorganic phosphorus, total protein, and amylolytic activity level in the selected samples while X-ray density was identified by computed microtomography.

Results: All samples of pathological joint fluid have shown a high level of amylolytic activity as compared to the synovial fluid from healthy joints. The relationship between the level of amylolytic activity in synovia and specific joint pathology has been identified. It has also been found that uric acid values, inorganic phosphorus concentrations, and total protein in various types of joint damage may influence X-ray density of the synovial fluid. Correlations between the studied indices have been established.

Conclusion: New data on the level of synovia amylolytic activity has been obtained in one non-inflammatory and six different inflammatory diseases. Pathogenically determined correlation between the microtomographic index of synovial fluid density and concentrations of uric acid, inorganic phosphorus, total protein has been confirmed. Specific indicators of X-ray density of synovia in various joint pathologies as well as unidirectional and multidirectional data in comparison with the norm allow us to consider X-ray microtomography as a method that reveals additional details during investigation of synovial fluid density and brings new surrogate markers for the study of pathogenetic mechanisms of the development, differentiation, and treatment of various joint pathologies.

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来源期刊
Sovremennye Tehnologii v Medicine
Sovremennye Tehnologii v Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
1.80
自引率
0.00%
发文量
38
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