纳米载体功能化策略在皮肤癌治疗中的靶向药物递送:目前的进展和未来的挑战。

IF 5 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Leonardo Delello Di Filippo, Mariana Carlomagno de Paula, Jonatas Lobato Duarte, Geanne Aparecida de Paula, Isadora Frigieri, Marlus Chorilli
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引用次数: 0

摘要

简介:皮肤癌是世界上最常见的癌症,近年来发病率不断上升。虽然传统的化学疗法和放射疗法已被用于治疗,但这些疗法有一些局限性,如缺乏选择性和显著的副作用。靶向纳米载体已经成为治疗皮肤癌的一种很有前途的方法。涉及领域:本文综述了靶向纳米载体在皮肤癌治疗中的应用。它涵盖了各种类型的靶向纳米载体,包括脂质体,聚合物纳米颗粒,树状大分子和无机纳米颗粒。专家意见:在靶向纳米颗粒的临床转化之前,仍有一些挑战需要解决,例如优化其特性,开发可靠且稳健的表征方法,以及在临床试验中评估其安全性和有效性。推进这些研究的另一个关键方面是需要改善与针对皮肤癌的纳米药物的毒性和调节相关的监管方面。总的来说,靶向纳米载体在开发安全有效的皮肤癌治疗方法方面具有很大的潜力,有助于改善患者的预后和整体生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nanocarrier functionalization strategies for targeted drug delivery in skin cancer therapy: current progress and upcoming challenges.

Introduction: Skin cancer is the most common form of cancer worldwide, with increasing incidence rates in recent years. Although conventional chemotherapy and radiation therapy have been used for its treatment, these therapies have several limitations such as lack of selectivity and significant side effects. Targeted nanocarriers have emerged as a promising approach for the treatment of skin cancer.

Areas covered: This review article provides an overview of targeted nanocarriers for skin cancer treatment. It covers the various types of targeted nanocarriers, including liposomes, polymeric nanoparticles, dendrimers, and inorganic nanoparticles.

Expert opinion: There are still several challenges that need to be addressed before the clinical translation of targeted nanoparticles, such as optimization of their properties, development of reliable and robust characterization methods, and evaluation of their safety and efficacy in clinical trials. Another key aspect for the advancement of these studies is the need to improve regulatory aspects related to the toxicity and regulation of nanomedicines targeting skin cancer. Overall, targeted nanocarriers hold great potential for the development of safe and effective treatments for skin cancer, which can contribute to a better prognosis and overall patients' life quality.

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来源期刊
CiteScore
11.10
自引率
3.00%
发文量
104
审稿时长
3 months
期刊介绍: Expert Opinion on Drug Delivery (ISSN 1742-5247 [print], 1744-7593 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles covering all aspects of drug delivery research, from initial concept to potential therapeutic application and final relevance in clinical use. Each article is structured to incorporate the author’s own expert opinion on the scope for future development.
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