Lidiane Rocha Mota, Ivone da Silva Duarte, Thais Rodrigues Galache, Katia Maria Dos Santos Pretti, Orlando Chiarelli Neto, Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Daniela de Fátima Teixeira da Silva, Christiane Pavani
{"title":"光生物调节减少眼周皱纹体积30%:一项随机对照试验。","authors":"Lidiane Rocha Mota, Ivone da Silva Duarte, Thais Rodrigues Galache, Katia Maria Dos Santos Pretti, Orlando Chiarelli Neto, Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Daniela de Fátima Teixeira da Silva, Christiane Pavani","doi":"10.1089/photob.2022.0114","DOIUrl":null,"url":null,"abstract":"<p><p><b><i>Objective:</i></b> This study aimed to evaluate red and amber light-emitting diode protocols for facial rejuvenation at the same light dose. <b><i>Background:</i></b> The demand for minimally invasive cosmetic procedures to address skin aging has grown throughout the world. <i>In vitro</i> red and amber photobiomodulation (PBM) has been shown to improve collagen synthesis. Meanwhile, red PBM has already been studied in clinical trials; however, a comparison of the use of different wavelengths at the same light dose to reduce periocular wrinkles has not yet been performed. <b><i>Methods:</i></b> This split-face, randomized clinical trial recruited 137 women (40-65 years old) presenting with skin phototypes II-IV and Glogau photoaging scale types II-IV. The individuals received 10 sessions for 4 weeks of red (660 nm) and amber (590 nm) PBM (3.8 J/cm<sup>2</sup>), one at each side of the face. The outcomes, measured before and after the treatments, were the periocular wrinkle volume measured by VisioFace<sup>®</sup> RD equipment; hydration measured by the Corneometer CM 825; skin elasticity measured by the Cutometer Dual MPA 580; and quality of life determined by adapted versions of validated questionnaires [Melasma Quality of Life Scale-Brazilian Portuguese (MelasQoL-BP) and Skindex-29]. <b><i>Results:</i></b> There was a significant reduction in wrinkle volume after red (31.6%) and amber (29.9%) PBM. None of the treatments improved skin hydration and viscoelasticity. Both questionnaires showed improvements in participants' quality of life. <b><i>Conclusions:</i></b> PBM, both at red and amber wavelengths, is an effective tool for rejuvenation, producing a 30% wrinkle volume reduction. The technique has strong potential in patients with diabetes or those presenting with keloids, conditions for which highly inflammatory rejuvenating procedures are not indicated. Clinical trial registration number: REBEC-6YFCBM.</p>","PeriodicalId":20111,"journal":{"name":"Photobiomodulation, photomedicine, and laser surgery","volume":"41 2","pages":"48-56"},"PeriodicalIF":0.0000,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Photobiomodulation Reduces Periocular Wrinkle Volume by 30%: A Randomized Controlled Trial.\",\"authors\":\"Lidiane Rocha Mota, Ivone da Silva Duarte, Thais Rodrigues Galache, Katia Maria Dos Santos Pretti, Orlando Chiarelli Neto, Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Daniela de Fátima Teixeira da Silva, Christiane Pavani\",\"doi\":\"10.1089/photob.2022.0114\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b><i>Objective:</i></b> This study aimed to evaluate red and amber light-emitting diode protocols for facial rejuvenation at the same light dose. <b><i>Background:</i></b> The demand for minimally invasive cosmetic procedures to address skin aging has grown throughout the world. <i>In vitro</i> red and amber photobiomodulation (PBM) has been shown to improve collagen synthesis. 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The outcomes, measured before and after the treatments, were the periocular wrinkle volume measured by VisioFace<sup>®</sup> RD equipment; hydration measured by the Corneometer CM 825; skin elasticity measured by the Cutometer Dual MPA 580; and quality of life determined by adapted versions of validated questionnaires [Melasma Quality of Life Scale-Brazilian Portuguese (MelasQoL-BP) and Skindex-29]. <b><i>Results:</i></b> There was a significant reduction in wrinkle volume after red (31.6%) and amber (29.9%) PBM. None of the treatments improved skin hydration and viscoelasticity. Both questionnaires showed improvements in participants' quality of life. <b><i>Conclusions:</i></b> PBM, both at red and amber wavelengths, is an effective tool for rejuvenation, producing a 30% wrinkle volume reduction. The technique has strong potential in patients with diabetes or those presenting with keloids, conditions for which highly inflammatory rejuvenating procedures are not indicated. 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引用次数: 4
摘要
目的:本研究旨在评价红色和琥珀色发光二极管在相同光剂量下的面部年轻化方案。背景:在世界范围内,对解决皮肤老化的微创美容手术的需求已经增长。在体外,红色和琥珀色光生物调节(PBM)已被证明可以促进胶原蛋白的合成。同时,红色PBM已经在临床试验中进行了研究;然而,在相同的光剂量下使用不同波长的光来减少眼周皱纹的比较尚未进行。方法:这项裂脸随机临床试验招募了137名女性(40-65岁),她们的皮肤光型为II-IV型,Glogau光老化量表为II-IV型。受试者接受10次为期4周的红色(660纳米)和琥珀色(590纳米)PBM (3.8 J/cm2),面部两侧各一次。治疗前后测量的结果是:VisioFace®RD设备测量的眼周皱纹体积;Corneometer CM 825测定水合作用;皮肤弹性测量仪Dual MPA 580;生活质量由经过验证的调查问卷[黄褐斑生活质量量表-巴西葡萄牙语(MelasQoL-BP)和skinindex -29]的改编版本确定。结果:红色PBM和琥珀色PBM术后,皱纹体积明显减少(31.6%)。没有一种治疗方法能改善皮肤的水合作用和粘弹性。两份问卷都显示了参与者生活质量的改善。结论:红色和琥珀色波长的PBM都是有效的年轻化工具,可使皱纹体积减少30%。该技术在糖尿病患者或有瘢痕疙瘩的患者中具有很大的潜力,这些患者不适合进行高度炎症的恢复手术。临床试验注册号:rebec6yfcbm。
Photobiomodulation Reduces Periocular Wrinkle Volume by 30%: A Randomized Controlled Trial.
Objective: This study aimed to evaluate red and amber light-emitting diode protocols for facial rejuvenation at the same light dose. Background: The demand for minimally invasive cosmetic procedures to address skin aging has grown throughout the world. In vitro red and amber photobiomodulation (PBM) has been shown to improve collagen synthesis. Meanwhile, red PBM has already been studied in clinical trials; however, a comparison of the use of different wavelengths at the same light dose to reduce periocular wrinkles has not yet been performed. Methods: This split-face, randomized clinical trial recruited 137 women (40-65 years old) presenting with skin phototypes II-IV and Glogau photoaging scale types II-IV. The individuals received 10 sessions for 4 weeks of red (660 nm) and amber (590 nm) PBM (3.8 J/cm2), one at each side of the face. The outcomes, measured before and after the treatments, were the periocular wrinkle volume measured by VisioFace® RD equipment; hydration measured by the Corneometer CM 825; skin elasticity measured by the Cutometer Dual MPA 580; and quality of life determined by adapted versions of validated questionnaires [Melasma Quality of Life Scale-Brazilian Portuguese (MelasQoL-BP) and Skindex-29]. Results: There was a significant reduction in wrinkle volume after red (31.6%) and amber (29.9%) PBM. None of the treatments improved skin hydration and viscoelasticity. Both questionnaires showed improvements in participants' quality of life. Conclusions: PBM, both at red and amber wavelengths, is an effective tool for rejuvenation, producing a 30% wrinkle volume reduction. The technique has strong potential in patients with diabetes or those presenting with keloids, conditions for which highly inflammatory rejuvenating procedures are not indicated. Clinical trial registration number: REBEC-6YFCBM.