用于治疗皮肤相关疾病的小干扰rna纳米疗法。

IF 5 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Yen-Tzu Chang, Tse-Hung Huang, Ahmed Alalaiwe, Erica Hwang, Jia-You Fang
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引用次数: 0

摘要

RNA干扰(RNAi)在皮肤相关疾病的治疗中显示出巨大的潜力,因为小干扰RNA (siRNA)可以有效地沉默特定基因。siRNA皮肤递送系统的设计对于保护核酸,同时促进皮肤靶向和细胞摄取非常重要。将siRNA捕获到纳米载体中可以实现这些目标,有助于改善靶向性、控制释放和增加转染。涵盖领域:综述了基于sirna的纳米治疗皮肤疾病的方法。首先,介绍了RNAi的机制,然后介绍了皮肤治疗的挑战。然后,描述了用于siRNA皮肤递送的不同纳米颗粒类型。随后,我们介绍了纳米颗粒如何增强siRNA皮肤渗透的机制。最后,对纳米siRNA在皮肤疾病管理中的应用进行了综述。专家意见:纳米治疗RNAi的潜在应用允许一种新的皮肤应用策略。需要进一步的临床研究来证实细胞或动物实验的发现。纳米颗粒产品的大规模生产能力和可重复性对于转化为商业化也至关重要。纳米载体的siRNA递送应该优化以达到皮肤靶向而没有毒性风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Small interfering RNA-based nanotherapeutics for treating skin-related diseases.

Introduction: RNA interference (RNAi) has demonstrated great potential in treating skin-related diseases, as small interfering RNA (siRNA) can efficiently silence specific genes. The design of skin delivery systems for siRNA is important to protect the nucleic acid while facilitating both skin targeting and cellular ingestion. Entrapment of siRNA into nanocarriers can accomplish these aims, contributing to improved targeting, controlled release, and increased transfection.

Areas covered: The siRNA-based nanotherapeutics for treating skin disorders are summarized. First, the mechanisms of RNAi are presented, followed by the introduction of challenges for skin therapy. Then, the different nanoparticle types used for siRNA skin delivery are described. Subsequently, we introduce the mechanisms of how nanoparticles enhance siRNA skin penetration. Finally, the current investigations associated with nanoparticulate siRNA application in skin disease management are reviewed.

Expert opinion: The potential application of nanotherapeutic RNAi allows for a novel skin application strategy. Further clinical studies are required to confirm the findings in the cell-based or animal experiments. The capability of large-scale production and reproducibility of nanoparticle products are also critical for translation to commercialization. siRNA delivery by nanocarriers should be optimized to attain cutaneous targeting without the risk of toxicity.

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来源期刊
CiteScore
11.10
自引率
3.00%
发文量
104
审稿时长
3 months
期刊介绍: Expert Opinion on Drug Delivery (ISSN 1742-5247 [print], 1744-7593 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles covering all aspects of drug delivery research, from initial concept to potential therapeutic application and final relevance in clinical use. Each article is structured to incorporate the author’s own expert opinion on the scope for future development.
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