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A 28-year-old Afro-Asian, 16-week twin pregnant woman attended our center due to fatigue and fever. At her first antenatal visit at 10 weeks, dichorionic twin pregnancy was present. One of the fetuses had negative fetal cardiac activity, the other did not have any abnormal ultrasonographic findings and findings were consistent with 10 weeks. The nuchal translucency and nasal bone were normal. She had a healthy pregnancy eight years previously, which delivered through a normal vaginal route. Fetal ultrasonographic findings were consistent with 16 weeks twin pregnancy with vanishing twin at hospital admission. The amniotic fluid of the live fetus was normal, the sac margins were regular, and the cervical length was 40 mm. The dead fetus was consistent with 9-10 weeks. The patient was hospitalized because of fatigue and fever. In the laboratory findings, the C-reactive protein (CRP) value was very high (105 mg/L) and D-dimer value was 2250 ng/mL. White blood cell count and international normalized ratio were in normal ranges. Hemoglobin value was only 7 mg/dL. She has febrile episodes, ranging 37.2-38 °C. No microorganisms were grown. No findings suggestive of choroamnionitis were found. We started empric antibiotics (piperacillin-tazobactam) for suspicion of common microorganisms. In three days, there was no decline in the CRP values or procalcitonin levels were detected. COVID-19 polymerase chain reaction (PCR