老年人c反应蛋白、抑郁症状和社会关系的种族差异:一个有调节的网络分析。

IF 1.9 4区 医学 Q2 NURSING
Chiyoung Lee, Se Hee Min
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引用次数: 3

摘要

引言:我们引入调节网络分析作为一种综合方法来评估种族对老年人c -反应蛋白(CRP)和抑郁症状之间关系的调节作用。本研究进一步探讨了观察到的关系在调整社会关系时的差异。方法:对国家社会生活、健康和老龄化项目(2010-2011)的横断面数据进行二次分析,包括2,880名老年人。我们使用了来自流行病学研究中心抑郁量表的不同抑郁症状域(抑郁影响、低积极影响、躯体症状和人际问题)。社会关系通过社会整合、社会支持和社会压力来评估。使用R-package mgm构建了调节网络。种族调节者被编码为白人/非裔美国人种族群体。结果:在CRP与抑郁症状的调节网络中,CRP-“人际问题”边缘仅在非裔美国人中存在。CRP-“躯体症状”优势存在于两个种族中,且优势权重相等。在调整社会关系后,上述模式保持不变,但边缘权重有所减弱。此外,我们还观察到只有非裔美国人的crp -社会压力和社会融合-“抑郁影响”边缘。讨论:种族可能会缓和老年人CRP和抑郁症状之间的关系,社会关系可能是分析它们时需要考虑的重要协变量。本研究作为起始点;未来的网络调查将受益于利用更多的当代老年人队列,获得具有不同种族/民族背景和重要协变量的大样本量。讨论了当前研究中几个重要的方法学问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Racial Differences in C-Reactive Protein, Depression Symptoms, and Social Relationships in Older Adults: A Moderated Network Analysis.

Introduction: We introduce moderated network analysis as an integrative approach to assess the moderation effects of race on the relationship between C-reactive protein (CRP) and depression symptoms in older adults. This study further explores how the observed relationships differ adjusting for social relationships.

Methods: This secondary analysis of cross-sectional data from the National Social Life, Health, and Aging Project (2010-2011) includes 2,880 older adults. We used different depression symptom domains (depressed affect, low positive affect, somatic symptoms, and interpersonal problems) from the Center for Epidemiologic Studies-Depression Scale. Social relationships were assessed with measures of social integration, social support, and social strain. The moderated networks were constructed using the R-package mgm. The racial moderator was coded as White/African American racial groups.

Results: In the moderated networks of CRP and depression symptoms, CRP-"interpersonal problems" edge was present only among African Americans. CRP-"somatic symptoms" edge was present in both racial groups with equal edge weights. After adjusting for social relationships, the aforementioned patterns remained the same, but the edge weights were attenuated. We additionally observed CRP-social strain and social integration-"depressed affect" edges only in African Americans.

Discussion: Race may moderate the relationship between the CRP and depression symptoms in older adults and social relationships might be important covariates to consider while analyzing them. This study as an initiation point; future network investigations would benefit from leveraging more contemporary cohorts of older adults, gaining a large sample size with diverse racial/ethnic backgrounds, and important covariates. Several important methodological issues of the current study are addressed.

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来源期刊
CiteScore
5.10
自引率
4.00%
发文量
58
审稿时长
>12 weeks
期刊介绍: Biological Research For Nursing (BRN) is a peer-reviewed quarterly journal that helps nurse researchers, educators, and practitioners integrate information from many basic disciplines; biology, physiology, chemistry, health policy, business, engineering, education, communication and the social sciences into nursing research, theory and clinical practice. This journal is a member of the Committee on Publication Ethics (COPE)
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