严重 COVID-19 对角膜内皮细胞的影响--体内非接触式镜检分析。

IF 2.6 4区医学 Q2 OPHTHALMOLOGY

Ocular Immunology and Inflammation Pub Date : 2024-09-01 Epub Date: 2023-06-22 DOI:10.1080/09273948.2023.2219312

Nurettin Bayram, Cemal Ozsaygılı, Medine Gundogan, Sefa Unal, Fatma Bagci, Emine Pangal, I Sa Yuvacı

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引用次数: 0

摘要

目的：本研究旨在通过体内镜下显微镜观察严重 COVID-19 感染对角膜内皮的影响：这是一项观察性、前瞻性和对照研究，研究对象包括56名重症COVID-19患者的56只眼睛，与康复后的56只眼睛以及56名年龄和性别匹配的健康对照者的56只眼睛进行比较：结果：与健康对照组相比，内皮细胞密度在疾病活动期较低（p = .001），在康复后（p p p = .008，分别）和健康对照组（两者均为p p p = .002）下降得更多：这些结果可能是由于宿主与病毒之间的直接相互作用，也可能与免疫调节失调、亚临床角膜内皮炎或病毒介导的炎症有关。

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The Impact of Severe COVID-19 on Corneal Endothelial Cells-Analysis of the In Vivo Noncontact Specular Microscopy.

Purpose: This study aimed to investigate the effects of severe COVID-19 infection on the corneal endothelium via in vivo specular microscopy.

Methods: This was an observational, prospective, and controlled study including 56 eyes of 56 severe COVID-19 patients, compared to after-recovery and 56 eyes of 56 age- and gender-matched healthy controls.

Results: Endothelial cell density was lower in the active disease period compared to healthy controls (p = .001) and decreased even more after recovery (p < .0001). After recovery, the average cell area and coefficient of variation were higher compared to the active disease period (p < .0001 and p = .008, respectively) and the healthy controls (for both, p < .0001), whereas hexagonality was lower (p < .0001). Central corneal thickness increased in the active disease period compared to after recovery (p < .0001) and healthy controls (p = .002).

Conclusions: These results may be due to direct host-virus interaction or linked to immune dysregulation, subclinical corneal endotheliitis, or still yet a viral-mediated inflammation.

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.