胃癌中obg样atp酶1的临床病理意义及其与蜗牛的关系。

IF 0.7 4区 医学 Q4 PATHOLOGY
Juan Wang, Qinghua Cao, Zhiqing Wang
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引用次数: 0

摘要

Obg样atp酶1 (OLA1)是p环NTPases的Obg家族成员,最近在几种人类癌细胞中被检测到。然而,其在胃癌中的表达类型及临床意义尚不清楚。本研究通过从open Gene Expression Omnibus数据库下载的2个数据集和30个癌组织中检测胃癌(GC)中OLA1的mRNA水平。对334例胃癌患者行免疫组化检测胃癌及其与蜗牛的关系。结果显示,GC组织中OLA1 mRNA和蛋白表达升高。OLA1的高表达与肿瘤大小、淋巴结转移和肿瘤结节转移分期等侵袭性特征显著相关(p = 0.0146, p = 0.0037, p < 0.001)。此外,高水平的OLA1预示着更差的总生存期。多因素Cox回归分析显示,OLA1高表达是总生存差的独立预后因素(p = 0.009)。此外,OLA1表达与Snail呈正相关,两者结合表明胃癌患者的预后准确性有所提高。OLA1的高表达预示着胃癌患者预后不良,可能成为胃癌治疗的新靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinicopathological significance of  Obg-like ATPase 1 and its association with Snail in gastric cancer.

Obg-like ATPase 1 (OLA1) is a member of the Obg family of P-loop NTPases and has recently been detected in several human cancer cells. However, its expression type and clinical relevance in gastric cancer remains unclear. In the present study, mRNA level of OLA1 in gastric cancer (GC) was detected in 2 datasets downloaded from the open Gene Expression Omnibus database and 30 cancer tissues. Immunohistochemistry was performed on GC and its association with Snail in 334 GC patients. The results showed that OLA1 mRNA and protein were elevated in GC tissues. High expression of OLA1 was significantly associated with aggressive features, such as tumour size, lymph-node-metastasis and tumour-nodus-metastases stage ( p = 0.0146, p = 0.0037, p < 0.001, respectively). Moreover, high levels of OLA1 predicted worse overall survival. Multivariate Cox regression analysis indicated that high expression of OLA1 was an independent prognostic factor for poor overall survival ( p = 0.009). Additionally, OLA1 expression was positively correlated with Snail, and a combination of them revealed improved prognostic accuracy for GC patients. High expression of OLA1 predicts poor prognosis in GC patients and may be serviced as a novel target for GC.

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来源期刊
CiteScore
1.00
自引率
0.00%
发文量
21
审稿时长
>12 weeks
期刊介绍: Polish Journal of Pathology is an official magazine of the Polish Association of Pathologists and the Polish Branch of the International Academy of Pathology. For the last 18 years of its presence on the market it has published more than 360 original papers and scientific reports, often quoted in reviewed foreign magazines. A new extended Scientific Board of the quarterly magazine comprises people with recognised achievements in pathomorphology and biology, including molecular biology and cytogenetics, as well as clinical oncology. Polish scientists who are working abroad and are international authorities have also been invited. Apart from presenting scientific reports, the magazine will also play a didactic and training role.
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