婴儿特应性皮炎的脂质组学和代谢组学:与早期营养有何关联?

IF 1.3 Q3 PEDIATRICS
Angelica Dessì, Camilla Di Maria, Roberta Pintus, Vassilios Fanos, Alice Bosco
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引用次数: 0

摘要

尽管特应性皮炎(AD)在儿童中的发病率很高(20%),而且有可能持续到成年,对患者的生活质量造成重要影响,并带来巨大的社会和经济损失,但迄今为止,特应性皮炎的复杂情况尚未完全明了。最新的科学证据对注意力缺失症做出了新的解释,强调了环境的重要作用,尤其是发育早期的营养。事实上,新的迹象似乎表明,除极少数情况外,排除性饮食会产生有害影响,在辅食喂养期间,长期喂养是无用的,母乳喂养对高危人群有一定益处,尽管这种益处很微弱。在这种情况下,有必要进行代谢组学和脂质组学研究,以便更深入地了解这种病症背后复杂的代谢网络。事实上,注意力缺失症患儿体内代谢内容的改变已得到强调,尤其是与肠道微生物群的相关性。初步的脂质体研究表明,深入了解皮肤屏障的变化有助于改进婴儿护肤品的开发。因此,研究不同过敏表型的反应有助于更好地管理和了解患者,从而提供必要的早期干预措施,从发育的最初阶段开始调节免疫反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lipidomics and Metabolomics in Infant Atopic Dermatitis: What's the Correlation with Early Nutrition?

To date, the complex picture of atopic dermatitis (AD) has not yet been fully clarified, despite the important prevalence of this disease in the pediatric population (20%) and the possibility of persistence into adulthood, with important implications for the quality of life of those affected, as well as significant social and financial costs. The most recent scientific evidence suggests a new interpretation of AD, highlighting the important role of the environment, particularly that of nutrition in the early stages of development. In fact, the new indications seem to point out the harmful effect of elimination diets, except in rare cases, the uselessness of chrono-insertions during complementary feeding and some benefits, albeit weak, of breastfeeding in those at greater risk. In this context, metabolomics and lipidomics can be necessary for a more in-depth knowledge of the complex metabolic network underlying this pathology. In fact, an alteration of the metabolic contents in children with AD has been highlighted, especially in correlation to the intestinal microbiota. While preliminary lipidomic studies showed the usefulness of a more in-depth knowledge of the alterations of the skin barrier to improve the development of baby skin care products. Therefore, investigating the response of different allergic phenotypes could be useful for better patient management and understanding, thus providing an early intervention on dysbiosis necessary to regulate the immune response from the earliest stages of development.

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来源期刊
CiteScore
4.30
自引率
0.00%
发文量
66
期刊介绍: Current Pediatric Reviews publishes frontier reviews on all the latest advances in pediatric medicine. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in pediatric medicine.
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