玻璃体内注射雷尼珠单抗治疗视网膜中央静脉阻塞引起的黄斑水肿对脉络膜发现和功能形态学参数的影响。

IF 2 4区 医学 Q2 OPHTHALMOLOGY
Ophthalmic Research Pub Date : 2023-01-01 Epub Date: 2023-06-16 DOI:10.1159/000531498
Kanako Yasuda, Hidetaka Noma, Eri Oyama, Kosei Yanagida, Masaki Asakage, Masahiko Shimura
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引用次数: 0

摘要

引言:很少有研究检测抗血管内皮生长因子治疗对视网膜中央静脉阻塞(CRVO)引起的黄斑水肿患者的黄斑下脉络膜厚度(SCT)、脉络膜血流量、房水闪光、生长水平和炎症因子的影响。方法:在58例玻璃体内注射雷珠单抗(IRI)治疗的CRVO引起的黄斑水肿患者中,我们回顾性评估了最佳矫正视力(BCVA,评估为最小分辨角的对数[logMAR])、8个水性因素(通过悬浮阵列)、平均模糊率,水性光斑(用激光光斑仪)以及SCT和中央黄斑厚度(CMT;通过光学相干断层扫描)。结果:4周后,IRI导致BCVA和CMT显著改善,SCT、脉络膜MBR和水性闪光显著减少。SCT与胎盘生长因子显著正相关,与血小板衍生生长因子AA显著负相关,SCT的变化与BCVA(logMAR)的变化显著负相关。含水火炬与SCT呈显著负相关。结论:生长和炎症因子可能与SCT有关,IRI治疗CRVO引起的黄斑水肿后SCT的变化可能与BCVA的变化有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effects of Intravitreal Ranibizumab Injection to Treat Macular Edema due to Central Retinal Vein Occlusion on Choroidal Findings and Functional-Morphological Parameters.

Effects of Intravitreal Ranibizumab Injection to Treat Macular Edema due to Central Retinal Vein Occlusion on Choroidal Findings and Functional-Morphological Parameters.

Effects of Intravitreal Ranibizumab Injection to Treat Macular Edema due to Central Retinal Vein Occlusion on Choroidal Findings and Functional-Morphological Parameters.

Effects of Intravitreal Ranibizumab Injection to Treat Macular Edema due to Central Retinal Vein Occlusion on Choroidal Findings and Functional-Morphological Parameters.

Introduction: Little research has examined the effects of anti-vascular endothelial growth factor therapy on subfoveal choroidal thickness (SCT), choroidal blood flow, aqueous flare, and humor levels of growth and inflammatory factors in patients with macular edema due to central retinal vein occlusion (CRVO).

Methods: In 58 patients with macular edema due to CRVO treated by intravitreal ranibizumab injection (IRI), we retrospectively assessed best-corrected visual acuity (BCVA, assessed as the logarithm of the minimum angle of resolution [logMAR]), 8 aqueous factors (by suspension array), mean blur rate (MBR; estimated by laser speckle flowgraphy as a measure of choroidal blood flow), aqueous flare (with a laser flare meter), and SCT and central macular thickness (CMT; by optical coherence tomography).

Results: After 4 weeks, IRI resulted in a significant improvement in BCVA and CMT and a significant reduction in SCT, choroidal MBR, and aqueous flare. SCT was significantly positively correlated with placental growth factor and significantly negatively correlated with platelet-derived growth factor-AA, and change in SCT was significantly negatively correlated with change in BCVA (logMAR). Aqueous flare was significantly negatively correlated with SCT.

Conclusion: Growth and inflammatory factors may be associated with SCT, and changes in SCT may be associated with changes in BCVA after IRI to treat macular edema due to CRVO.

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来源期刊
Ophthalmic Research
Ophthalmic Research 医学-眼科学
CiteScore
3.80
自引率
4.80%
发文量
75
审稿时长
6-12 weeks
期刊介绍: ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.
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