沃尔巴克氏体与病毒之间的相互作用,以及通过蚊子种群替换控制虫媒病毒。

IF 4.9 4区 医学 Q1 PARASITOLOGY
Pathogens and Global Health Pub Date : 2023-05-01 Epub Date: 2022-10-07 DOI:10.1080/20477724.2022.2117939
Thomas H Ant, Maria Vittoria Mancini, Cameron J McNamara, Stephanie M Rainey, Steven P Sinkins
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引用次数: 0

摘要

研究表明,在转入主要虫媒病毒载体埃及伊蚊体内后,细胞内的几株沃尔巴克氏菌可抑制登革热、寨卡和基孔肯雅病毒的传播,这些病毒是重要的人类病原体,在全球范围内造成严重的发病率和死亡率。除了抑制病原体外,许多沃尔巴克氏菌菌株还能操纵宿主的繁殖,从而使细菌具有入侵昆虫种群的能力。因此,人们将沃尔巴克氏菌作为登革热控制工具来使用,据试验报告,沃尔巴克氏菌释放地区的登革热传播显著减少。在此,我们讨论了沃尔巴克氏菌抑制病毒的可能机制以及对登革热控制长期成功的影响。我们还考虑了一些报告中提出的证据,即在特定条件下,沃尔巴克氏菌可能会导致某些病毒的复制增强,并得出结论认为,这些都不应该引起人们对应用沃尔巴克氏菌控制虫媒病毒的担忧。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

<i>Wolbachia</i>-Virus interactions and arbovirus control through population replacement in mosquitoes.

<i>Wolbachia</i>-Virus interactions and arbovirus control through population replacement in mosquitoes.

<i>Wolbachia</i>-Virus interactions and arbovirus control through population replacement in mosquitoes.

Wolbachia-Virus interactions and arbovirus control through population replacement in mosquitoes.

Following transfer into the primary arbovirus vector Aedes aegypti, several strains of the intracellular bacterium Wolbachia have been shown to inhibit the transmission of dengue, Zika, and chikungunya viruses, important human pathogens that cause significant morbidity and mortality worldwide. In addition to pathogen inhibition, many Wolbachia strains manipulate host reproduction, resulting in an invasive capacity of the bacterium in insect populations. This has led to the deployment of Wolbachia as a dengue control tool, and trials have reported significant reductions in transmission in release areas. Here, we discuss the possible mechanisms of Wolbachia-virus inhibition and the implications for long-term success of dengue control. We also consider the evidence presented in several reports that Wolbachia may cause an enhancement of replication of certain viruses under particular conditions, and conclude that these should not cause any concerns with respect to the application of Wolbachia to arbovirus control.

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来源期刊
Pathogens and Global Health
Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY
CiteScore
6.00
自引率
0.00%
发文量
60
审稿时长
6-12 weeks
期刊介绍: Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.
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