Jeeyong Shin, Megha Andrews, Lindsey DeJean, Nicole Debski, Alyssa Exarchakis, Julia Fleming, Roshni Gandhi, Christina Hum, Abyson Kalladanthyil, Rohini Maddigunta, Logan Napoli, Cynthia Nguyen, Reshma Paul, Nicole Schmalbach, Joseph Sichel, Samuel Snyder, Matthew Stern, Subhadra Thampi, Jesse Viggiano, Gabriella Yao, Krystal Hunter, Satyajeet Roy
{"title":"老年患者心房颤动的相关危险因素。","authors":"Jeeyong Shin, Megha Andrews, Lindsey DeJean, Nicole Debski, Alyssa Exarchakis, Julia Fleming, Roshni Gandhi, Christina Hum, Abyson Kalladanthyil, Rohini Maddigunta, Logan Napoli, Cynthia Nguyen, Reshma Paul, Nicole Schmalbach, Joseph Sichel, Samuel Snyder, Matthew Stern, Subhadra Thampi, Jesse Viggiano, Gabriella Yao, Krystal Hunter, Satyajeet Roy","doi":"10.14740/jocmr4884","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) is the most common arrhythmia with a growing prevalence worldwide, especially in the elderly population. Patients with AF are at higher risk of serious life-threatening events and complications that may lead to long-term sequelae and reduce quality of life. The aim of our study was to examine the association of additional risk factors and comorbid medical conditions with AF in patients 65 years, or older.</p><p><strong>Methods: </strong>We performed a retrospective electronic medical record review of patients aged 65 years and older, who visited our internal medicine office between July 1, 2020 and June 30, 2021.</p><p><strong>Results: </strong>Among 2,433 patients, 418 patients (17.2%) had AF. Our analysis showed that for each unit increased in age, there was a 4.5% increase in the odds of AF (95% confidence interval (CI) 2.2-6.9%; P < 0.001). Compared to patients of Caucasian descent, African-American patients had significantly decreased odds of AF (odds ratio (OR) 0.274, 95% CI 0.141 - 0.531; P < 0.001). Patients with hypertension had 2.241 greater odds of AF (95% CI 1.421 - 3.534; P = 0.001). Additional comorbidities with significantly greater odds of AF included other cardiac arrhythmias (OR 2.523, 95% CI 1.720 - 3.720; P < 0.001), congestive heart failure (OR 3.111, 95% CI 1.674 - 5.784; P < 0.001), osteoarthritis (OR 3.014, 95% CI 2.138 - 4.247; P < 0.001), liver disease (OR 2.129, 95% CI 1.164 - 3.893; P = 0.014), and colorectal disease (OR 1.500 95% CI 1.003 - 2.243; P = 0.048). Comorbidities with significantly decreased odds of AF included other rheumatological disorder (OR 0.144, 95% CI 0.086 - 0.243; P < 0.001), non-steroidal anti-inflammatory drugs (NSAIDs) use (OR 0.206, 95% CI 0.125 - 0.338; P < 0.001), and corticosteroid use (OR 0.553, 95% CI 0.374 - 0.819; P = 0.003).</p><p><strong>Conclusions: </strong>Increasing age, hypertension, presence of other cardiac arrhythmias, congestive heart failure, osteoarthritis, liver disease, and colorectal disease are associated with increased odds of having AF.</p>","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"15 3","pages":"148-160"},"PeriodicalIF":0.0000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6d/0a/jocmr-15-148.PMC10079365.pdf","citationCount":"2","resultStr":"{\"title\":\"Risk Factors Associated With Atrial Fibrillation in Elderly Patients.\",\"authors\":\"Jeeyong Shin, Megha Andrews, Lindsey DeJean, Nicole Debski, Alyssa Exarchakis, Julia Fleming, Roshni Gandhi, Christina Hum, Abyson Kalladanthyil, Rohini Maddigunta, Logan Napoli, Cynthia Nguyen, Reshma Paul, Nicole Schmalbach, Joseph Sichel, Samuel Snyder, Matthew Stern, Subhadra Thampi, Jesse Viggiano, Gabriella Yao, Krystal Hunter, Satyajeet Roy\",\"doi\":\"10.14740/jocmr4884\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Atrial fibrillation (AF) is the most common arrhythmia with a growing prevalence worldwide, especially in the elderly population. Patients with AF are at higher risk of serious life-threatening events and complications that may lead to long-term sequelae and reduce quality of life. The aim of our study was to examine the association of additional risk factors and comorbid medical conditions with AF in patients 65 years, or older.</p><p><strong>Methods: </strong>We performed a retrospective electronic medical record review of patients aged 65 years and older, who visited our internal medicine office between July 1, 2020 and June 30, 2021.</p><p><strong>Results: </strong>Among 2,433 patients, 418 patients (17.2%) had AF. Our analysis showed that for each unit increased in age, there was a 4.5% increase in the odds of AF (95% confidence interval (CI) 2.2-6.9%; P < 0.001). Compared to patients of Caucasian descent, African-American patients had significantly decreased odds of AF (odds ratio (OR) 0.274, 95% CI 0.141 - 0.531; P < 0.001). Patients with hypertension had 2.241 greater odds of AF (95% CI 1.421 - 3.534; P = 0.001). Additional comorbidities with significantly greater odds of AF included other cardiac arrhythmias (OR 2.523, 95% CI 1.720 - 3.720; P < 0.001), congestive heart failure (OR 3.111, 95% CI 1.674 - 5.784; P < 0.001), osteoarthritis (OR 3.014, 95% CI 2.138 - 4.247; P < 0.001), liver disease (OR 2.129, 95% CI 1.164 - 3.893; P = 0.014), and colorectal disease (OR 1.500 95% CI 1.003 - 2.243; P = 0.048). 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引用次数: 2
摘要
背景:房颤(AF)是最常见的心律失常，在世界范围内的发病率越来越高，尤其是在老年人群中。房颤患者发生严重危及生命事件和并发症的风险较高，可能导致长期后遗症并降低生活质量。本研究的目的是检查65岁及以上患者房颤的其他危险因素和合并症的相关性。方法:我们对2020年7月1日至2021年6月30日期间到我们内科办公室就诊的65岁及以上患者进行了回顾性电子病历回顾。结果:在2433例患者中，418例患者(17.2%)患有房颤。我们的分析显示，年龄每增加一个单位，房颤的几率增加4.5%(95%置信区间(CI) 2.2-6.9%;P < 0.001)。与白种人相比，非洲裔美国人患房颤的几率显著降低(优势比(OR) 0.274, 95% CI 0.141 - 0.531;P < 0.001)。高血压患者发生房颤的几率高出2.241 (95% CI 1.421 - 3.534;P = 0.001)。房颤发生率显著增加的其他合并症包括其他心律失常(OR 2.523, 95% CI 1.720 - 3.720;P < 0.001)，充血性心力衰竭(OR 3.111, 95% CI 1.674 - 5.784;P < 0.001)，骨关节炎(OR 3.014, 95% CI 2.138 - 4.247;P < 0.001)，肝脏疾病(OR 2.129, 95% CI 1.164 - 3.893;P = 0.014)和结直肠疾病(OR 1.500 95% CI 1.003 - 2.243;P = 0.048)。房颤发生率显著降低的合并症包括其他风湿病(OR 0.144, 95% CI 0.086 - 0.243;P < 0.001)，非甾体抗炎药(NSAIDs)的使用(OR 0.206, 95% CI 0.125 - 0.338;P < 0.001)和皮质类固醇使用(OR 0.553, 95% CI 0.374 - 0.819;P = 0.003)。结论:年龄增长、高血压、其他心律失常、充血性心力衰竭、骨关节炎、肝脏疾病和结直肠疾病与房颤发生率增加相关。
Risk Factors Associated With Atrial Fibrillation in Elderly Patients.
Background: Atrial fibrillation (AF) is the most common arrhythmia with a growing prevalence worldwide, especially in the elderly population. Patients with AF are at higher risk of serious life-threatening events and complications that may lead to long-term sequelae and reduce quality of life. The aim of our study was to examine the association of additional risk factors and comorbid medical conditions with AF in patients 65 years, or older.
Methods: We performed a retrospective electronic medical record review of patients aged 65 years and older, who visited our internal medicine office between July 1, 2020 and June 30, 2021.
Results: Among 2,433 patients, 418 patients (17.2%) had AF. Our analysis showed that for each unit increased in age, there was a 4.5% increase in the odds of AF (95% confidence interval (CI) 2.2-6.9%; P < 0.001). Compared to patients of Caucasian descent, African-American patients had significantly decreased odds of AF (odds ratio (OR) 0.274, 95% CI 0.141 - 0.531; P < 0.001). Patients with hypertension had 2.241 greater odds of AF (95% CI 1.421 - 3.534; P = 0.001). Additional comorbidities with significantly greater odds of AF included other cardiac arrhythmias (OR 2.523, 95% CI 1.720 - 3.720; P < 0.001), congestive heart failure (OR 3.111, 95% CI 1.674 - 5.784; P < 0.001), osteoarthritis (OR 3.014, 95% CI 2.138 - 4.247; P < 0.001), liver disease (OR 2.129, 95% CI 1.164 - 3.893; P = 0.014), and colorectal disease (OR 1.500 95% CI 1.003 - 2.243; P = 0.048). Comorbidities with significantly decreased odds of AF included other rheumatological disorder (OR 0.144, 95% CI 0.086 - 0.243; P < 0.001), non-steroidal anti-inflammatory drugs (NSAIDs) use (OR 0.206, 95% CI 0.125 - 0.338; P < 0.001), and corticosteroid use (OR 0.553, 95% CI 0.374 - 0.819; P = 0.003).
Conclusions: Increasing age, hypertension, presence of other cardiac arrhythmias, congestive heart failure, osteoarthritis, liver disease, and colorectal disease are associated with increased odds of having AF.
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