纳米颗粒在呼吸道黏液中的扩散受黏液纤毛清除的影响:数学模型的综述。

IF 2 4区 医学 Q3 RESPIRATORY SYSTEM
Mohammad Hadi Sedaghat, Mehrdad Behnia, Omid Abouali
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引用次数: 1

摘要

背景:由于颗粒污染物的重要性、传染性疾病的传播以及靶向区域药物的治疗递送,人体气道中颗粒的吸入和沉积引起了相当大的关注。我们总结了目前气道表面液体(ASL)颗粒沉积受粘膜纤毛清除(MCC)影响的研究现状,并指出了需要进一步研究的领域。方法:我们的目标是回顾重点描述MCC几何的控制和本构方程,然后描述纤毛力的数学模型,粘液流变特性,以及解决修正时相关Navier-Stokes方程的数值方法。本文还回顾了MCC影响下ASL中粒子沉积的数学模型、欧拉和拉格朗日方法下ASL中的粒子输运,并讨论了该层中相应的质量输运问题。必要时,将数值预测与相关实验数据进行对比。结果:结果表明黏液和纤毛周液体的平均流速受黏液流变特性和纤毛异常的强烈影响。然而,目前大多数关于粘液纤维间距、纤毛跳动频率和颗粒表面化学的文献都是基于颗粒在ASL上的沉积,并考虑ASL速度的固定值。实际ASL流态对颗粒沉积的影响是有限的。此外,没有其他研究对ASL给药过程中黏液层的非均匀性和粘弹性特性进行建模。结论:受MCC影响的ASL给药控制方程假设简化导致数值结果存在一定局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nanoparticle Diffusion in Respiratory Mucus Influenced by Mucociliary Clearance: A Review of Mathematical Modeling.

Background: Inhalation and deposition of particles in human airways have attracted considerable attention due to importance of particulate pollutants, transmission of infectious diseases, and therapeutic delivery of drugs at targeted areas. We summarize current state-of-the art research in particle deposition on airway surface liquid (ASL) influenced by mucociliary clearance (MCC) by identifying areas that need further investigation. Methodology: We aim to review focus on governing and constitutive equations describing MCC geometry followed by description of mathematical modeling of ciliary forces, mucus rheology properties, and numerical approaches to solve modified time-dependent Navier-Stokes equations. We also review mathematical modeling of particle deposition in ASL influenced by MCC, particle transport in ASL in terms of Eulerian and Lagrangian approaches, and discuss the corresponding mass transport issues in this layer. Whenever required, numerical predictions are contrasted with the pertinent experimental data. Results: Results indicate that mean mucus and periciliary liquid velocities are strongly influenced by mucus rheological characteristics as well as ciliary abnormalities. However, most of the currently available literature on mucus fiber spacing, ciliary beat frequency, and particle surface chemistry is based on particle deposition on ASL by considering a fixed value of ASL velocity. The effects of real ASL flow regimes on particle deposition in this layer are limited. In addition, no other study is available on modeling nonhomogeneous and viscoelastic characteristics of mucus layer on ASL drug delivery. Conclusion: Simplification of assumptions on governing equations of drug delivery in ASL influenced by MCC leads to imposing some limitations on numerical results.

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来源期刊
CiteScore
6.70
自引率
2.90%
发文量
34
审稿时长
>12 weeks
期刊介绍: Journal of Aerosol Medicine and Pulmonary Drug Delivery is the only peer-reviewed journal delivering innovative, authoritative coverage of the health effects of inhaled aerosols and delivery of drugs through the pulmonary system. The Journal is a forum for leading experts, addressing novel topics such as aerosolized chemotherapy, aerosolized vaccines, methods to determine toxicities, and delivery of aerosolized drugs in the intubated patient. Journal of Aerosol Medicine and Pulmonary Drug Delivery coverage includes: Pulmonary drug delivery Airway reactivity and asthma treatment Inhalation of particles and gases in the respiratory tract Toxic effects of inhaled agents Aerosols as tools for studying basic physiologic phenomena.
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