阿波啡舌下膜和左旋多巴对OFF发作患者的运动反应。

IF 2.3 Q3 CLINICAL NEUROLOGY
Stuart H Isaacson, Alyssa Bowling, Ian Zhang, Eric Pappert, Fabrizio Stocchi
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引用次数: 1

摘要

目的:评价卡比多巴/左旋多巴(CD/LD)和阿波啡舌下膜(SL-APO)对帕金森病和OFF发作患者运动改善的时机。方法:对两项研究进行事后汇总分析,评估运动障碍学会统一帕金森病评定量表第三部分(MDS-UPDRS-III)评分和研究者评定的FULL ON评分。结果:在规定的首次每日CD/LD剂量后15分钟和30分钟,MDS-UPDRS-III评分的平均改善分别为-6.7和-16.3,达到FULL ON的患者分别为6.5%和41.8%。在优化SL-APO剂量后,MDS-UPDRS-III评分的平均改善为-13.9和-22.9,34.7%和81.0%的患者达到了FULL ON。结论:SL-APO与卡比多巴/左旋多巴合用可有效治疗迟发性ON。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Motor response with apomorphine sublingual film and levodopa in patients with OFF episodes.

Aim: Evaluate timing of motor improvement with carbidopa/levodopa (CD/LD) and apomorphine sublingual film (SL-APO) in patients with Parkinson's disease and OFF episodes. Methods: A post hoc pooled analysis from two studies assessed Movement Disorder Society Unified Parkinson's Disease Rating Scale Part III (MDS-UPDRS-III) scores and investigator-rated FULL ON. Results: At 15 and 30 min following the prescribed first daily CD/LD dose, mean improvements in MDS-UPDRS-III scores were -6.7 and -16.3, respectively, and FULL ON was achieved by 6.5 and 41.8% of patients. Following an optimized SL-APO dose, mean improvements in MDS-UPDRS-III scores were -13.9 and -22.9, and FULL ON was achieved by 34.7 and 81.0% of patients. Conclusion: Concomitant administration of SL-APO with carbidopa/levodopa may be useful for delayed ON.

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CiteScore
4.30
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