糖尿病足部骨髓炎及其治疗。

Vidyaalakshmi Venkatesan, Jayakumar Rangasamy
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引用次数: 1

摘要

糖尿病是一种快速生长的慢性代谢紊乱,与足部溃疡广泛相关。这些溃疡的主要挑战是伤口感染、炎症反应改变和血管生成不足,这可能使截肢手术复杂化。足部由于其结构,成为最容易发生并发症的部位,并且由于潮湿的性质,感染率较高,主要是脚趾之间。因此,感染率明显较高。糖尿病患者的创面愈合是一个动态过程,通常由于免疫功能不佳而延迟。糖尿病相关的足部神经病变和灌注紊乱可导致足部感觉丧失。由于重复的机械压力,这种神经病变可能进一步成为溃疡发展的一个危险因素,后来可能被延伸到骨骼的微生物入侵感染,并引起一种称为足部骨髓炎的感染。本文就骨感染的病理生理学、骨感染治疗和骨再生的生物材料及其局限性进行了综述,并展望了它们的发展前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Diabetic Pedal Osteomyelitis and Its Treatment.

Diabetic Pedal Osteomyelitis and Its Treatment.

Diabetic Pedal Osteomyelitis and Its Treatment.

Diabetic Pedal Osteomyelitis and Its Treatment.

Diabetes is a fast-growing chronic metabolic disorder that is widely associated with foot ulcers. The major challenge among these ulcers is wound infections, altered inflammatory responses, and a lack of angiogenesis that can complicate limb amputation. The foot, because of its architecture, becomes the part most prone to complications and the infection rate is higher mainly between the toes due to the humid nature. Therefore, the infection rate is significantly higher. Wound healing in diabetes is a dynamic process usually delayed due to poor immune function. Diabetes-related pedal neuropathy and perfusion disturbances can lead to a loss of sensation in the foot. This neuropathy can further be a risk factor for ulcer development due to repetitive mechanical stress that later might get infected by the invasion of microorganisms extending to the bone and causing an infection called pedal osteomyelitis. This review details the pathophysiology, the biomaterials aiding in the infection cure and regeneration of bone along with their limitations, as well as their future prospects.

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