Einav G Levin, Sharon Tzelnick, Daniel Yaacobi, Igor Vainer, Aviram Mizrachi, Aron Popovtzer, Ethan Soudry
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引用次数: 0
摘要
目的:本研究的目的是回顾鼻窦恶性肿瘤(SNMs)患者治疗的长期并发症和这些并发症的危险因素。方法:回顾性分析2001年至2018年在三级医疗中心接受SNMs治疗的所有患者。共纳入77例患者。主要结局指标是治疗后的长期并发症。结果:总体而言，41例(53%)患者出现了长期并发症，其中最常见的是鼻窦相关(22例，29%)和眶/眼相关(18例，23%)。在多变量回归分析中，放疗是长期并发症的唯一显著预测因子(p = 0.001, OR = 18.86, CI = 3.31-107.6)。未观察到长期并发症与肿瘤分期、手术方式或放射剂量/方式之间的关联。视神经平均辐射剂量≥50 Gy与≥3级视力损害相关(100% vs 3%;P = 0.006)。疾病复发的放射治疗与额外的长期并发症相关(56% vs 11%;P = 0.04)。结论:SNMs的治疗有大量的长期并发症，这些并发症与放射治疗显著相关。
Long-term complications associated with the management of sinonasal malignancies: a single center experience.
Objective: The aim of this study was to review the long-term complications associated with treatment of patients with sinonasal malignancies (SNMs) and risk factors for these complications.
Methods: A retrospective analysis of all patients treated for SNMs at a tertiary care center between 2001 and 2018. A total of 77 patients were included. The primary outcome measure was post-treatment long-term complications.
Results: Overall, long-term complications were identified in 41 patients (53%), and the most common were sinonasal (22 patients, 29%) and orbital/ocular-related (18 patients, 23%). In a multivariate regression analysis, irradiation was the only significant predictor of long-term complications (p = 0.001, OR = 18.86, CI = 3.31-107.6). No association was observed between long-term complications and tumour stage, surgical modality, or radiation dose/modality. Mean radiation dose ≥ 50 Gy to the optic nerve was associated with grade ≥ 3 visual acuity impairment (100% vs 3%; p = 0.006). Radiation therapy for disease recurrence was associated with additional long-term complications (56% vs 11%; p = 0.04).
Conclusions: Treatment of SNMs has substantial long-term complications, which are significantly associated with radiation therapy.
期刊介绍：
Acta Otorhinolaryngologica Italica first appeared as “Annali di Laringologia Otologia e Faringologia” and was founded in 1901 by Giulio Masini.
It is the official publication of the Italian Hospital Otology Association (A.O.O.I.) and, since 1976, also of the Società Italiana di Otorinolaringoiatria e Chirurgia Cervico-Facciale (S.I.O.Ch.C.-F.).
The journal publishes original articles (clinical trials, cohort studies, case-control studies, cross-sectional surveys, and diagnostic test assessments) of interest in the field of otorhinolaryngology as well as clinical techniques and technology (a short report of unique or original methods for surgical techniques, medical management or new devices or technology), editorials (including editorial guests – special contribution) and letters to the Editor-in-Chief.
Articles concerning science investigations and well prepared systematic reviews (including meta-analyses) on themes related to basic science, clinical otorhinolaryngology and head and neck surgery have high priority.
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