{"title":"古肿瘤学孤立性骨软骨瘤:公元前4世纪意大利南部Pontecagnano地区一例报告","authors":"Giulia Riccomi , Giacomo Aringhieri , Antonia Serritella , Valentina Giuffra","doi":"10.1016/j.ijpp.2023.04.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>This study presents a new case of solitary osteochondroma (SOC) identified on the proximal tibia of a 4th-century BCE individual from Pontecagnano (Salerno, Italy) with an aim to contribute to differential diagnosis of bone tumors in archeological contexts.</p></div><div><h3>Materials</h3><p>Paleopathological assessment of a male individual with an estimated age-at death of 45.9–62.9 years brought to light during the archaeological excavations in the funerary sector of ‘Sica de Concillis’ within the necropolis of Pontecagnano.</p></div><div><h3>Methods</h3><p>Macroscopic and radiographic analyses were performed for diagnostic purposes.</p></div><div><h3>Results</h3><p>The proximal portion of the right tibia exhibited a large exophytic bone formation extending from the anteromedial to the posteromedial portion of the diaphysis. The x-ray confirmed the lesion being characterized by regular trabecular bone tissue with cortico-medullary continuity.</p></div><div><h3>Conclusions</h3><p>The lesion observed is diagnostic of sessile SOC, a neoplasm that must have had aesthetic and, possibly, neurovascular complications due to its large size.</p></div><div><h3>Significance</h3><p>By offering a detailed description of a case of tibial osteochondroma and discussing the possible complications the individual might have experienced during life, this study highlights the role and importance of benign bone tumors in paleo-oncology.</p></div><div><h3>Limitations</h3><p>Histological analysis was not carried out in order to preserve the integrity of the affected tibia.</p></div><div><h3>Suggestions for further research</h3><p>More attention should be devoted to benign tumors in paleopathology as their occurrence and manifestations in the past will lead to a better understanding of their impacts on the quality of life of affected individuals and to greater knowledge of their natural history.</p></div>","PeriodicalId":48817,"journal":{"name":"International Journal of Paleopathology","volume":"41 ","pages":"Pages 101-109"},"PeriodicalIF":1.3000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Solitary osteochondromas in paleo-oncology: A case report from 4th-century BCE Pontecagnano (southern Italy)\",\"authors\":\"Giulia Riccomi , Giacomo Aringhieri , Antonia Serritella , Valentina Giuffra\",\"doi\":\"10.1016/j.ijpp.2023.04.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>This study presents a new case of solitary osteochondroma (SOC) identified on the proximal tibia of a 4th-century BCE individual from Pontecagnano (Salerno, Italy) with an aim to contribute to differential diagnosis of bone tumors in archeological contexts.</p></div><div><h3>Materials</h3><p>Paleopathological assessment of a male individual with an estimated age-at death of 45.9–62.9 years brought to light during the archaeological excavations in the funerary sector of ‘Sica de Concillis’ within the necropolis of Pontecagnano.</p></div><div><h3>Methods</h3><p>Macroscopic and radiographic analyses were performed for diagnostic purposes.</p></div><div><h3>Results</h3><p>The proximal portion of the right tibia exhibited a large exophytic bone formation extending from the anteromedial to the posteromedial portion of the diaphysis. The x-ray confirmed the lesion being characterized by regular trabecular bone tissue with cortico-medullary continuity.</p></div><div><h3>Conclusions</h3><p>The lesion observed is diagnostic of sessile SOC, a neoplasm that must have had aesthetic and, possibly, neurovascular complications due to its large size.</p></div><div><h3>Significance</h3><p>By offering a detailed description of a case of tibial osteochondroma and discussing the possible complications the individual might have experienced during life, this study highlights the role and importance of benign bone tumors in paleo-oncology.</p></div><div><h3>Limitations</h3><p>Histological analysis was not carried out in order to preserve the integrity of the affected tibia.</p></div><div><h3>Suggestions for further research</h3><p>More attention should be devoted to benign tumors in paleopathology as their occurrence and manifestations in the past will lead to a better understanding of their impacts on the quality of life of affected individuals and to greater knowledge of their natural history.</p></div>\",\"PeriodicalId\":48817,\"journal\":{\"name\":\"International Journal of Paleopathology\",\"volume\":\"41 \",\"pages\":\"Pages 101-109\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2023-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Paleopathology\",\"FirstCategoryId\":\"89\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1879981723000244\",\"RegionNum\":3,\"RegionCategory\":\"地球科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PALEONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Paleopathology","FirstCategoryId":"89","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1879981723000244","RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PALEONTOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的本研究报告了一个来自意大利Salerno Pontecagnano的公元前4世纪个体胫骨近端发现的孤立性骨软骨瘤(SOC)的新病例，旨在为考古背景下骨肿瘤的鉴别诊断做出贡献。在Pontecagnano墓地' Sica de Concillis '墓葬区的考古发掘中，一名男性的死亡年龄估计为45.9-62.9岁。方法采用显微和放射学分析诊断。结果右胫骨近端有大量外生骨形成，从骨干前内侧延伸至骨干后内侧。x线证实病变的特征是有规则的骨小梁骨组织，具有皮质-髓质连续性。结论观察到的病变可诊断为无根性SOC，由于其体积大，必须有美观，可能有神经血管并发症。通过对一例胫骨骨软骨瘤的详细描述，并讨论患者一生中可能经历的并发症，本研究强调了良性骨肿瘤在古肿瘤学中的作用和重要性。限制:为了保持受影响胫骨的完整性，未进行组织学分析。良性肿瘤在古病理学中的发生和表现将有助于我们更好地了解其对患者生活质量的影响和对其自然史的认识，因此应给予更多的关注。
Solitary osteochondromas in paleo-oncology: A case report from 4th-century BCE Pontecagnano (southern Italy)
Objective
This study presents a new case of solitary osteochondroma (SOC) identified on the proximal tibia of a 4th-century BCE individual from Pontecagnano (Salerno, Italy) with an aim to contribute to differential diagnosis of bone tumors in archeological contexts.
Materials
Paleopathological assessment of a male individual with an estimated age-at death of 45.9–62.9 years brought to light during the archaeological excavations in the funerary sector of ‘Sica de Concillis’ within the necropolis of Pontecagnano.
Methods
Macroscopic and radiographic analyses were performed for diagnostic purposes.
Results
The proximal portion of the right tibia exhibited a large exophytic bone formation extending from the anteromedial to the posteromedial portion of the diaphysis. The x-ray confirmed the lesion being characterized by regular trabecular bone tissue with cortico-medullary continuity.
Conclusions
The lesion observed is diagnostic of sessile SOC, a neoplasm that must have had aesthetic and, possibly, neurovascular complications due to its large size.
Significance
By offering a detailed description of a case of tibial osteochondroma and discussing the possible complications the individual might have experienced during life, this study highlights the role and importance of benign bone tumors in paleo-oncology.
Limitations
Histological analysis was not carried out in order to preserve the integrity of the affected tibia.
Suggestions for further research
More attention should be devoted to benign tumors in paleopathology as their occurrence and manifestations in the past will lead to a better understanding of their impacts on the quality of life of affected individuals and to greater knowledge of their natural history.
期刊介绍：
Paleopathology is the study and application of methods and techniques for investigating diseases and related conditions from skeletal and soft tissue remains. The International Journal of Paleopathology (IJPP) will publish original and significant articles on human and animal (including hominids) disease, based upon the study of physical remains, including osseous, dental, and preserved soft tissues at a range of methodological levels, from direct observation to molecular, chemical, histological and radiographic analysis. Discussion of ways in which these methods can be applied to the reconstruction of health, disease and life histories in the past is central to the discipline, so the journal would also encourage papers covering interpretive and theoretical issues, and those that place the study of disease at the centre of a bioarchaeological or biocultural approach. Papers dealing with historical evidence relating to disease in the past (rather than history of medicine) will also be published. The journal will also accept significant studies that applied previously developed techniques to new materials, setting the research in the context of current debates on past human and animal health.
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