粪便微生物群移植是保持青春的秘诀

IF 5.3 3区 医学 Q2 CELL BIOLOGY
Yiming Meng , Jing Sun , Guirong Zhang
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引用次数: 4

摘要

衰老不仅表现在细胞层面,如端粒缩短和细胞周期停滞,还表现在器官和有机体层面,如智力下降、眼睛干涩、肠道炎症、肌肉萎缩、皱纹等。当肠道微生物群(通常被称为“宿主的虚拟器官”)不能正常运作时,可能会导致一系列健康问题,包括但不限于炎症性肠病、肥胖、代谢性肝病、II型糖尿病、心血管疾病、癌症,甚至神经系统疾病。粪便菌群移植(FMT)是恢复健康肠道细菌的有效策略。它可以通过将健康人粪便中的功能性细菌移植到患者的肠道中来逆转衰老对消化系统、大脑和视力的影响。这为未来研究利用微生物群作为与衰老相关疾病的治疗靶点铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fecal microbiota transplantation holds the secret to youth

Aging shows itself not just at the cellular level, with shortened telomeres and cell cycle arrest, but also at the organ and organismal level, with diminished brainpower, dry eyes, intestinal inflammation, muscular atrophy, wrinkles, etc. When the gut microbiota, often called the "virtual organ of the host," fails to function normally, it can lead to a cascade of health problems including, but not limited to, inflammatory bowel disease, obesity, metabolic liver disease, type II diabetes, cardiovascular disease, cancer, and even neurological disorders. An effective strategy for restoring healthy gut bacteria is fecal microbiota transplantation (FMT). It can reverse the effects of aging on the digestive system, the brain, and the vision by transplanting the functional bacteria found in the excrement of healthy individuals into the gut tracts of patients. This paves the way for future research into using the microbiome as a therapeutic target for disorders associated with aging.

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来源期刊
CiteScore
11.10
自引率
1.90%
发文量
79
审稿时长
32 days
期刊介绍: Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms. Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.
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