骨肉瘤患者血清表面活性物质前体蛋白B与临床特性相关。

IF 2.4 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry and Cell Biology Pub Date : 2023-10-01 Epub Date: 2023-05-16 DOI:10.1139/bcb-2022-0179

Shi Feng, Di Fu, Yong Zhang, Le Zhang, Yingnan Ji, Hongqiu Li, Liang A

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引用次数: 0

摘要

寻找有效的非侵入性骨肉瘤预后因素至关重要。在本研究中，我们证明血清表面活性剂前蛋白B（pro-SFTPB）可能是骨肉瘤的潜在诊断指标。我们发现血清前SFTPB在骨肉瘤患者中高度表达，并对区分骨肉瘤患者和非骨肉瘤对照组具有良好的诊断价值。血清促SFTPB也与晚期临床分期、远处转移和较短的总生存期显著相关。此外，血清前SFTPB被证明是骨肉瘤的一个独立预后因素。总之，我们的研究表明血清促SFTPB可能是骨肉瘤的有用诊断因素。

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Serum pro-surfactant protein B is correlated with clinical properties in osteosarcoma patients.

It is critical to find efficient non-invasive prognostic factor for osteosarcoma. In this study, we demonstrated that serum protein of pro-surfactant protein B (pro-SFTPB) may be a potential diagnostic indicator in osteosarcoma. We found that serum pro-SFTPB was highly expressed in osteosarcoma patients and presented good diagnostic value to discern osteosarcoma patients from non-osteosarcoma control subjects. Serum pro-SFTPB was also significantly correlated with advanced clinical stage, distant metastasis, and shorter overall survival. In addition, serum pro-SFTPB was demonstrated to be an independent prognostic factor for osteosarcoma. Overall, our study demonstrated that serum pro-SFTPB may be a useful diagnostic factor for osteosarcoma.

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来源期刊

Biochemistry and Cell Biology 生物-生化与分子生物学

CiteScore

6.30

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Published since 1929, Biochemistry and Cell Biology explores every aspect of general biochemistry and includes up-to-date coverage of experimental research into cellular and molecular biology in eukaryotes, as well as review articles on topics of current interest and notes contributed by recognized international experts. Special issues each year are dedicated to expanding new areas of research in biochemistry and cell biology.