Thomas Abrehart , Randy Suryadinata , Conor McCafferty , Jonathan Jacobson , Vera Ignjatovic , Phil Robinson , Nigel W. Crawford , Paul Monagle , Kanta Subbarao , Catherine Satzke , Danielle Wurzel
{"title":"SARS-CoV-2结合因子的年龄相关差异:儿童对严重COVID-19易感性降低的解释?","authors":"Thomas Abrehart , Randy Suryadinata , Conor McCafferty , Jonathan Jacobson , Vera Ignjatovic , Phil Robinson , Nigel W. Crawford , Paul Monagle , Kanta Subbarao , Catherine Satzke , Danielle Wurzel","doi":"10.1016/j.prrv.2022.01.008","DOIUrl":null,"url":null,"abstract":"<div><h3>Context</h3><p>In contrast with other respiratory viruses, children infected with SARS-CoV-2 are largely spared from severe COVID-19.</p></div><div><h3>Objectives</h3><p>To critically assess age-related differences in three host proteins involved in SARS-CoV-2 cellular entry: angiotensin-converting enzyme 2 (ACE2), transmembrane serine protease 2 (TMPRSS2) and furin.</p></div><div><h3>Methods</h3><p>We systematically searched Medline, Embase, and PubMed databases for relevant publications. Studies were eligible if they evaluated ACE2, TMPRSS2 or furin expression, methylation, or protein level in children.</p></div><div><h3>Results</h3><p>Sixteen papers were included. Age-dependent differences in membrane-bound and soluble ACE2 were shown in several studies, with <em>ACE2</em> expression increasing with age. TMPRSS2 and furin are key proteases involved in SARS-CoV-2 spike protein cleavage. <em>TMPRSS2</em> expression is increased by circulating androgens and is thus low in pre-pubertal children. Furin has not currently been well researched.</p></div><div><h3>Limitations</h3><p>High levels of study heterogeneity.</p></div><div><h3>Conclusions</h3><p>Low expression of key host proteins may partially explain the reduced incidence of severe COVID-19 among children, although further research is needed.</p></div>","PeriodicalId":4,"journal":{"name":"ACS Applied Energy Materials","volume":null,"pages":null},"PeriodicalIF":5.4000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823960/pdf/","citationCount":"6","resultStr":"{\"title\":\"Age-related differences in SARS-CoV-2 binding factors: An explanation for reduced susceptibility to severe COVID-19 among children?\",\"authors\":\"Thomas Abrehart , Randy Suryadinata , Conor McCafferty , Jonathan Jacobson , Vera Ignjatovic , Phil Robinson , Nigel W. Crawford , Paul Monagle , Kanta Subbarao , Catherine Satzke , Danielle Wurzel\",\"doi\":\"10.1016/j.prrv.2022.01.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Context</h3><p>In contrast with other respiratory viruses, children infected with SARS-CoV-2 are largely spared from severe COVID-19.</p></div><div><h3>Objectives</h3><p>To critically assess age-related differences in three host proteins involved in SARS-CoV-2 cellular entry: angiotensin-converting enzyme 2 (ACE2), transmembrane serine protease 2 (TMPRSS2) and furin.</p></div><div><h3>Methods</h3><p>We systematically searched Medline, Embase, and PubMed databases for relevant publications. Studies were eligible if they evaluated ACE2, TMPRSS2 or furin expression, methylation, or protein level in children.</p></div><div><h3>Results</h3><p>Sixteen papers were included. Age-dependent differences in membrane-bound and soluble ACE2 were shown in several studies, with <em>ACE2</em> expression increasing with age. TMPRSS2 and furin are key proteases involved in SARS-CoV-2 spike protein cleavage. <em>TMPRSS2</em> expression is increased by circulating androgens and is thus low in pre-pubertal children. Furin has not currently been well researched.</p></div><div><h3>Limitations</h3><p>High levels of study heterogeneity.</p></div><div><h3>Conclusions</h3><p>Low expression of key host proteins may partially explain the reduced incidence of severe COVID-19 among children, although further research is needed.</p></div>\",\"PeriodicalId\":4,\"journal\":{\"name\":\"ACS Applied Energy Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2022-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823960/pdf/\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Energy Materials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1526054222000094\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Energy Materials","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1526054222000094","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Age-related differences in SARS-CoV-2 binding factors: An explanation for reduced susceptibility to severe COVID-19 among children?
Context
In contrast with other respiratory viruses, children infected with SARS-CoV-2 are largely spared from severe COVID-19.
Objectives
To critically assess age-related differences in three host proteins involved in SARS-CoV-2 cellular entry: angiotensin-converting enzyme 2 (ACE2), transmembrane serine protease 2 (TMPRSS2) and furin.
Methods
We systematically searched Medline, Embase, and PubMed databases for relevant publications. Studies were eligible if they evaluated ACE2, TMPRSS2 or furin expression, methylation, or protein level in children.
Results
Sixteen papers were included. Age-dependent differences in membrane-bound and soluble ACE2 were shown in several studies, with ACE2 expression increasing with age. TMPRSS2 and furin are key proteases involved in SARS-CoV-2 spike protein cleavage. TMPRSS2 expression is increased by circulating androgens and is thus low in pre-pubertal children. Furin has not currently been well researched.
Limitations
High levels of study heterogeneity.
Conclusions
Low expression of key host proteins may partially explain the reduced incidence of severe COVID-19 among children, although further research is needed.
期刊介绍：
ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
