Usama E Abu Elhassan, Saad M A Alqahtani, Naif S Al Saglan, Ali Hawan, Khadejah M Alshahrani, Hana S Al-Malih, Mohammed A Alshehri, Faisal S Alqahtani, Fatimah Alshomrani, Roaa S Almtheeb, Ibrahim H E Feteih, Magda S R Abdelwahab, Ibrahim M A Mahmoud
{"title":"病毒合并感染对COVID-19患者临床结局和死亡率的影响:来自沙特阿拉伯的一项研究","authors":"Usama E Abu Elhassan, Saad M A Alqahtani, Naif S Al Saglan, Ali Hawan, Khadejah M Alshahrani, Hana S Al-Malih, Mohammed A Alshehri, Faisal S Alqahtani, Fatimah Alshomrani, Roaa S Almtheeb, Ibrahim H E Feteih, Magda S R Abdelwahab, Ibrahim M A Mahmoud","doi":"10.4081/mrm.2023.915","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>In COVID-19 patients undetected co-infections may have severe clinical implications associated with prolonged hospitalization, ICU admission, and mortality. Therefore, we aimed to investigate the impact of viral coinfections on the outcomes of hospitalized patients with COVID-19 in a large tertiary Saudi Arabian Hospital.</p><p><strong>Methods: </strong>A total of 178 adult patients with confirmed SARS-CoV-2 who were hospitalized at the Armed Forces Hospital Southern Region (AFHSR), Saudi Arabia, from March 1<sup>st</sup> to June 30<sup>th</sup> 2022, were enrolled. Real-time PCR for the detection of viral co<i>‑</i>infections was carried out. Cases (SARS-CoV-2 with viral coinfections) and control (SARS-CoV-2 mono-infection) groups were compared.</p><p><strong>Results: </strong>12/178 (7%) of enrolled COVID-19 patients had viral coinfections. 82/178 (46%) of patients were males. 58% of patients had comorbidities. During the study period, 4/12 (33%) and 21/166 (13%) cases and control patients died, p=0.047, respectively. Duration of hospitalization was the only significant independent factor associated with SARS-CoV-2 coinfections, OR 1.140, 95% CI 1.020-1.274, p=0.021.</p><p><strong>Conclusions: </strong>The findings of this study from a large tertiary Saudi Arabian Center revealed a prevalence of 7% for SARS-CoV-2 viral coinfections. SARS-CoV-2 coinfected patients had a significantly prolonged duration of hospitalization and higher mortality than those with SARS-CoV-2 alone. Future studies are needed.</p>","PeriodicalId":51135,"journal":{"name":"Multidisciplinary Respiratory Medicine","volume":"18 1","pages":"915"},"PeriodicalIF":2.0000,"publicationDate":"2023-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a0/d1/mrm-18-1-915.PMC10230552.pdf","citationCount":"0","resultStr":"{\"title\":\"Impact of viral co-infection on clinical outcomes and mortality of COVID-19 patients: a study from Saudi Arabia.\",\"authors\":\"Usama E Abu Elhassan, Saad M A Alqahtani, Naif S Al Saglan, Ali Hawan, Khadejah M Alshahrani, Hana S Al-Malih, Mohammed A Alshehri, Faisal S Alqahtani, Fatimah Alshomrani, Roaa S Almtheeb, Ibrahim H E Feteih, Magda S R Abdelwahab, Ibrahim M A Mahmoud\",\"doi\":\"10.4081/mrm.2023.915\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>In COVID-19 patients undetected co-infections may have severe clinical implications associated with prolonged hospitalization, ICU admission, and mortality. Therefore, we aimed to investigate the impact of viral coinfections on the outcomes of hospitalized patients with COVID-19 in a large tertiary Saudi Arabian Hospital.</p><p><strong>Methods: </strong>A total of 178 adult patients with confirmed SARS-CoV-2 who were hospitalized at the Armed Forces Hospital Southern Region (AFHSR), Saudi Arabia, from March 1<sup>st</sup> to June 30<sup>th</sup> 2022, were enrolled. Real-time PCR for the detection of viral co<i>‑</i>infections was carried out. Cases (SARS-CoV-2 with viral coinfections) and control (SARS-CoV-2 mono-infection) groups were compared.</p><p><strong>Results: </strong>12/178 (7%) of enrolled COVID-19 patients had viral coinfections. 82/178 (46%) of patients were males. 58% of patients had comorbidities. During the study period, 4/12 (33%) and 21/166 (13%) cases and control patients died, p=0.047, respectively. Duration of hospitalization was the only significant independent factor associated with SARS-CoV-2 coinfections, OR 1.140, 95% CI 1.020-1.274, p=0.021.</p><p><strong>Conclusions: </strong>The findings of this study from a large tertiary Saudi Arabian Center revealed a prevalence of 7% for SARS-CoV-2 viral coinfections. SARS-CoV-2 coinfected patients had a significantly prolonged duration of hospitalization and higher mortality than those with SARS-CoV-2 alone. 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Impact of viral co-infection on clinical outcomes and mortality of COVID-19 patients: a study from Saudi Arabia.
Background: In COVID-19 patients undetected co-infections may have severe clinical implications associated with prolonged hospitalization, ICU admission, and mortality. Therefore, we aimed to investigate the impact of viral coinfections on the outcomes of hospitalized patients with COVID-19 in a large tertiary Saudi Arabian Hospital.
Methods: A total of 178 adult patients with confirmed SARS-CoV-2 who were hospitalized at the Armed Forces Hospital Southern Region (AFHSR), Saudi Arabia, from March 1st to June 30th 2022, were enrolled. Real-time PCR for the detection of viral co‑infections was carried out. Cases (SARS-CoV-2 with viral coinfections) and control (SARS-CoV-2 mono-infection) groups were compared.
Results: 12/178 (7%) of enrolled COVID-19 patients had viral coinfections. 82/178 (46%) of patients were males. 58% of patients had comorbidities. During the study period, 4/12 (33%) and 21/166 (13%) cases and control patients died, p=0.047, respectively. Duration of hospitalization was the only significant independent factor associated with SARS-CoV-2 coinfections, OR 1.140, 95% CI 1.020-1.274, p=0.021.
Conclusions: The findings of this study from a large tertiary Saudi Arabian Center revealed a prevalence of 7% for SARS-CoV-2 viral coinfections. SARS-CoV-2 coinfected patients had a significantly prolonged duration of hospitalization and higher mortality than those with SARS-CoV-2 alone. Future studies are needed.
期刊介绍：
Multidisciplinary Respiratory Medicine is the official journal of the Italian Respiratory Society - Società Italiana di Pneumologia (IRS/SIP). The journal publishes on all aspects of respiratory medicine and related fields, with a particular focus on interdisciplinary and translational research.
The interdisciplinary nature of the journal provides a unique opportunity for researchers, clinicians and healthcare professionals across specialties to collaborate and exchange information. The journal provides a high visibility platform for the publication and dissemination of top quality original scientific articles, reviews and important position papers documenting clinical and experimental advances.
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